Maggiemycin, anhydromaggiemycin and processes for making

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

260376, 2603515, C07C 49798

Patent

active

045016992

ABSTRACT:
New anthracyclinones, including maggiemycin, anhydromaggiemycin and 7-oxidodaunorubicinone, have been prepared. Maggiemycin, anhydromaggiemycin, and 7-oxidodaunorubicinone all exhibit biological activity; they are toxic to cell lines KB, L1210 and P388.

REFERENCES:
21st Interscience Conference on Antimicrobial Agents and Chemotherapy-Chicago, Ill., (Nov. 1981), Abstract 182.
Maggiemycin and Anhydromaggiemycin: Two Novel Anthracyclinone Antitumor Antibiotics. Isolation, Structures, Partial Synthesis, and Biological Properties", by Ramesh C. Pandey et al.
Arcamone, F.: G. Franceschi, P. Orezzi, G. Cassinell, W. Barbieri & R. Mondelli: Daunomycin I., The Structure of Daunomycinone, J. Amer. Chem. Soc., 86: 5334-5335, 1964.
Arcamone, F.: Daunomycin and Related Antibiotics, In P. G. Sammes (ed.), Topics in Antibiotic Chemistry, vol. 2, pp. 89-239, Halsted Press, New York, 1978.
Arcamone, F., Doxorubicin: Anticancer Antibiotics, Academic Press, New York, p. 195, 1981.
Crooke, S. T.; DuVernay, V. H., Galvar, L. and A. W. Prestakyo; Structure-Activity Relationships of Anthracyclines Relative to Effects on Macromolecular Syntheses, Mol. Pharmacol., 14: 290-298, 1978.
DuVernay, V. H., J. M. Essery, T. W. Boyle, W. T. Bradner and S. T. Crooke, The Antitumor Effects of Anthracyclines, The Importance of the Carbomethoxy Group at Position-10 of Marcellomycin and Rudolfomycin, Mol. Pharmacol., 15: 341-356, 1979.
Hamilton, B.: R. White, J. McGuire, P. Montgomery, R. Stroshane, C. Kalita & R. Pandey: Improvement of the Daunorubicin Fermentation Realized at the 10,000 Liter Fermentor Scale, Advances in Biotechnology, vol. I, 1981, Pergamon Press, New York, pp. 63-68.
Kern, D. L.; R. H. Bunge, J. C. French & H. W. Dion: The Identification of .epsilon.-Rhodomycinone and 7-Deoxy-Daunorubicinol Aglycone in Daunorubicin Beers, J. Antibiotics, 30: 432-434, 1977.
McGuire, J. C.: B. K. Hamilton and R. J. White: Approaches to Development of the Daunorubicin Fermentation, Process. Biochem., 14: 2-5, 1979.
McGuire, J.; M. Thomas, R. Pandey, M. Toussaint & R. White: Biosynthesis of Daunorubicin Glycosides: Analysis with Blocked Mutants, Advances in Biotechnology, vol. III, 1981, pp. 117-122, Pergamon Press, New York.
Oki, T.: New Anthracycline Antibiotics, Jap. J. Antibiotics 30, (Suppl.) 570-584, 1977.
Pandey, R. C.; C. C. Kalita, R. J. White & M. W. Toussaint: Process Development in the Purification of Daunorubicin from Fermentation Broth, Process. Biochem., 14: pp. 6-13, 1979.
Pandey, R. C. & M. W. Toussaint: High-Performance Liquid Chromatography and Thin-Layer Chromatography of Anthracycline Antibiotics, Separation and Identification of Components of the Daunorubicin Complex from Fermentation Broth, J. Chromatogr., 198: 407-420, 1980.
Strauss, D. G.: Anthracyclines-Modern Tumor-Inhibiting Agents, Folia Microbiol., 23: 152-161, 1978.
Vanek, Z.; J. Tax, I. Komersova, P. Sedmera & J. Vokoun: Anthracyclines, Folia Microbiol., 22: 139-159, 1977.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Maggiemycin, anhydromaggiemycin and processes for making does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Maggiemycin, anhydromaggiemycin and processes for making, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Maggiemycin, anhydromaggiemycin and processes for making will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-516123

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.