Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-11-01
1985-02-26
Hollrah, Glennon H.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260376, 2603515, C07C 49798
Patent
active
045016992
ABSTRACT:
New anthracyclinones, including maggiemycin, anhydromaggiemycin and 7-oxidodaunorubicinone, have been prepared. Maggiemycin, anhydromaggiemycin, and 7-oxidodaunorubicinone all exhibit biological activity; they are toxic to cell lines KB, L1210 and P388.
REFERENCES:
21st Interscience Conference on Antimicrobial Agents and Chemotherapy-Chicago, Ill., (Nov. 1981), Abstract 182.
Maggiemycin and Anhydromaggiemycin: Two Novel Anthracyclinone Antitumor Antibiotics. Isolation, Structures, Partial Synthesis, and Biological Properties", by Ramesh C. Pandey et al.
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Arcamone, F.: Daunomycin and Related Antibiotics, In P. G. Sammes (ed.), Topics in Antibiotic Chemistry, vol. 2, pp. 89-239, Halsted Press, New York, 1978.
Arcamone, F., Doxorubicin: Anticancer Antibiotics, Academic Press, New York, p. 195, 1981.
Crooke, S. T.; DuVernay, V. H., Galvar, L. and A. W. Prestakyo; Structure-Activity Relationships of Anthracyclines Relative to Effects on Macromolecular Syntheses, Mol. Pharmacol., 14: 290-298, 1978.
DuVernay, V. H., J. M. Essery, T. W. Boyle, W. T. Bradner and S. T. Crooke, The Antitumor Effects of Anthracyclines, The Importance of the Carbomethoxy Group at Position-10 of Marcellomycin and Rudolfomycin, Mol. Pharmacol., 15: 341-356, 1979.
Hamilton, B.: R. White, J. McGuire, P. Montgomery, R. Stroshane, C. Kalita & R. Pandey: Improvement of the Daunorubicin Fermentation Realized at the 10,000 Liter Fermentor Scale, Advances in Biotechnology, vol. I, 1981, Pergamon Press, New York, pp. 63-68.
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McGuire, J. C.: B. K. Hamilton and R. J. White: Approaches to Development of the Daunorubicin Fermentation, Process. Biochem., 14: 2-5, 1979.
McGuire, J.; M. Thomas, R. Pandey, M. Toussaint & R. White: Biosynthesis of Daunorubicin Glycosides: Analysis with Blocked Mutants, Advances in Biotechnology, vol. III, 1981, pp. 117-122, Pergamon Press, New York.
Oki, T.: New Anthracycline Antibiotics, Jap. J. Antibiotics 30, (Suppl.) 570-584, 1977.
Pandey, R. C.; C. C. Kalita, R. J. White & M. W. Toussaint: Process Development in the Purification of Daunorubicin from Fermentation Broth, Process. Biochem., 14: pp. 6-13, 1979.
Pandey, R. C. & M. W. Toussaint: High-Performance Liquid Chromatography and Thin-Layer Chromatography of Anthracycline Antibiotics, Separation and Identification of Components of the Daunorubicin Complex from Fermentation Broth, J. Chromatogr., 198: 407-420, 1980.
Strauss, D. G.: Anthracyclines-Modern Tumor-Inhibiting Agents, Folia Microbiol., 23: 152-161, 1978.
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McGuire Jeffrey C.
Pandey Ramesh C.
Thomas Monica C.
Toussaint Margaret W.
Covington Raymond
Hollrah Glennon H.
Litton Bionetics, Inc.
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