MADR2 tumour suppressor gene

Details MADR2 tumour suppressor gene MADR2 tumour suppressor gene

1996-08-22

2000-01-25

Degen, Nancy

Chemistry: molecular biology and microbiology

Vector, per se

435325, 536 235, C12N 1563, C12N 500, C07H 2104

Patent

active

060177551

ABSTRACT:
A new human gene, MADR2, has been cloned and sequenced, and has been identified as a tumour suppressor gene. The protein encoded by the gene, MADR2, has been shown to participate in the TGF.beta. signalling pathway and to be phosphorylated on stimulation of the TGF.beta. receptor.

REFERENCES:
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Frank et al. Evidence that loss of chromosome 18q is associated with tumor progression. Cancer Res. vol. 57:824-827, Mar. 1, 1997.
Weatherall Scope and limitations of gene therapy. British Med Bull. vol. 51(1):1-11, Jul. 1995.
Orkin et al. Report adn recommendations or the panel to assess the NIH investment in research on gene therapy, Dec. 5, 1995.
Lechleider et al. Serine phosphorylation, chromosomal localization, and transforming growth facto-beta signal transduction by human bsp-1. J. Biol. Chem. vol. 271(30):17617-17620, Jul. 26, 1996.
Riggins et al. Mad-related genes in the human. Nature Genet. vol. 13:347-349, Jul. 1996.
Sekelsky et al. Genetic characterization and cloning of Mothers Against dpp, a gene required fro decapentaplegic function in Drosophila melanogaster. Genetics vol. 139:1347-1358, Mar. 1995.
Baker et al. A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes and Dev. vol. 10:1880-1889, Aug. 15, 1996.

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