MADD, a TNF receptor death domain ligand protein

Details MADD, a TNF receptor death domain ligand protein MADD, a TNF receptor death domain ligand protein

1996-08-15

1998-01-27

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 435 691, 435325, 435 701, 4353201, 530350, 530300, C07M 2104, C12N 1512, C12N 1585, C07K 14715

Patent

active

057123810

ABSTRACT:
Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

REFERENCES:
patent: 5296592 (1994-03-01), Dower et al.
patent: 5506340 (1996-04-01), Heavner
patent: 5563039 (1996-10-01), Goeddel et al.
Luban et al. 1995. Current Opinion Biotech. 6,59.
Waye et al., Protein Engineering 8:90 (1995).
Auffray et al., Life Sciences 318:263-272 (1995).
Rothe et al., Cell 78:681-692 (1994).
Song et al., The Journal of Biological Chemistry 269:22492-22495 (1994).
Tartaglia et al., Cell 74:845-853 (1993).
Boldin et al., The Journal of Biological Chemistry 270(1):387-391 (1995).
Hsu et al., Cell 81:495-504 (1995).
Boldin et al., FEBS Letters 367:39-44 (1995).
Schall et al., Cell 61:361-370 (1990).
Shimasaki et al., J. Biol. Chem. 266:10646-10653 (1991).
Saragovi et al., Bio/Technology 10:773-778 (1992).
McDowell et al., J. Amer. Chem. Soc. 114:9245-9253 (1992).
Kaufman et al., Nucleic Acids Res. 19:4485-4490 (1991).
Kaufman et al., Methods in Enzymology 185:537-566 (1990).
Gyuris et al., Cell 75:791-803 (1993).
Gietz et al., Nucleic Acids Res. 20:1425 (1992).
Miki et al. 1992 (Cancer Res. 52, 643).
Darnay et al 1994 (J. Biol. Chem. 269,20299).
Schall et al 1990 (Cell 61, 361).
Song et al 1994 (J. Biol. Chem. 269, 22492).
Shimasaki et al, 1991. J. Biol. Chem 266, 10646.
Keifer et al. 1992. J. Biol. Chem 267, 12692.

Affiliated with

Also associated with

Rating

MADD, a TNF receptor death domain ligand protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MADD, a TNF receptor death domain ligand protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MADD, a TNF receptor death domain ligand protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-343458