Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1976-06-09
1979-04-03
Ore, Dale R.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
34 10, 34 12, 34 60, 2604293, 260448R, 423462, 424 46, 424 66, 424 68, F26B 308, F26B 700, F26B 1900, C07F 700, C07F 506, C01B 700, A61J 307, A61K 738
Patent
active
041477669
ABSTRACT:
A process and apparatus are provided for making hollow macrospherical particles. The particles themselves are particularly adapted for use as anti-perspirants. The particles have a diameter between about 10 and 74 microns, preferably predominating between 15 and 44 microns, and a greater than unit density. As such, they are not subject to deep lung penetration. The process for producing the particles comprises providing a solution containing the materials from which the particles are made, diffusing the solution through small pores by centrifugal force such that the resulting hollow particles have a diameter greater than the pore diameter, and drying the solution droplets in a stream of heated air. The apparatus for producing the macrospherical particles comprises a centrifugal atomizer having a porous sintered metal filter ring which is rotated inside a spray drying chamber. The filter is treated to produce hollow macrospheres having substantially smooth outer walls of such thickness that they can withstand normal shipment and handling without significant fragmentation.
REFERENCES:
patent: 3014844 (1961-12-01), Thiel et al.
patent: 3516941 (1970-06-01), Matson
patent: 3619842 (1971-11-01), Maierson
patent: 3679102 (1972-07-01), Charle et al.
patent: 3691271 (1972-09-01), Charle et al.
patent: 3791987 (1974-02-01), Fanger
Armour Pharmaceutical Company
Mybeck Richard R.
Ore Dale R.
Schwarze William W.
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