Macroporous polymeric carrier for covalently binding proteins, i

Details Macroporous polymeric carrier for covalently binding proteins, i Macroporous polymeric carrier for covalently binding proteins, i

1979-07-12

1980-11-25

Foelak, Morton

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Cellular products or processes of preparing a cellular...

260 8, 435180, 435188, 521 53, 521145, 521150, C08J 900

Patent

active

042359732

ABSTRACT:
A macroporous crosslinked sytrene resin, used as a carrier for covalently binding proteins, which resin contains isocyanate, thioisocyanate or aldehyde groups as protein-binding groups and may or may not contain sulfonic acid groups--which may also be in the form of the sodium salt or of sulfonic acid amide groups--as hydrophilic groups.
The carrier according to the invention is prepared from a sulfochlorinated macroporous crosslinked styrene resin by reacting the sulfonic acid chloride groups with an .alpha.,.omega.-diamino compound, with hydrazine or with an .alpha.,.omega.-diaminodiether, converting any sulfonic acid chloride groups which may still be present to free sulfonic acid groups, their sodium salt or a sulfonamide group, and then reacting the terminal amino groups with phosgene, thiophosgene or a diisocyanate in order to produce the binding groups, which in turn fix a biologically active protein by covalent bonds.

REFERENCES:
patent: 3326866 (1967-06-01), Haag
patent: 3458976 (1969-08-01), Hollis
Helv. Chem. Acta, vol. XL, (1957), pp. 61-68.

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