Macroporous particles for cell cultivation or chromatography

Details Macroporous particles for cell cultivation or chromatography Macroporous particles for cell cultivation or chromatography

1987-10-28

1991-05-14

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

210656, 210660, 264 41, 264 46, 264 47, 435 41, 435 691, 435 711, 435177, 435178, 435180, 435182, 43524023, 43524024, 43524027, 435803, 530354, 935 59, 935106, C12P 2108, C12P 100, C12N 1102, C12N 500

Patent

active

050155768

ABSTRACT:
Particles which enclose cavities can be produced by adding a water-insoluble solid, liquid or gaseous cavity generating compound to an aqueous solution of matrix material. Subsequent to forming particles by dispersion in a water-insoluble dispersion medium, the matrix is rendered insoluble in water by cooling, by covalent cross-linking or by polymerization. The cavity generating compound is washed out, whereafter the particles can be used as ion exchangers in gel filtration processes, in hydrophobic chromatography or in affinity chromatography, optionally subsequent to derivatizing the particles. The particles can also be used to advantage as microcarriers in the cultivation of anchorage-dependent cells.

REFERENCES:
patent: 4157424 (1979-06-01), Boutle
patent: 4412947 (1983-11-01), Cioca
patent: 4500358 (1985-02-01), Mayer et al.
patent: 4565580 (1986-01-01), Miyata et al.
patent: 4609403 (1986-09-01), Wittmer et al.
patent: 4647536 (1987-03-01), Mosbach et al.
patent: 4798786 (1989-01-01), Tice et al.
patent: 4861718 (1989-08-01), Dean, Jr. et al.
patent: 4935365 (1990-06-01), Nilsson et al.

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