Macroporous particles as biocompatible chromatographic supports

Details Macroporous particles as biocompatible chromatographic supports Macroporous particles as biocompatible chromatographic supports

1991-09-13

1992-12-01

Foelak, Morton

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Cellular products or processes of preparing a cellular...

521 91, 521 92, 521 95, 521 96, 521122, 521123, 521141, 521146, 521147, 521149, 521150, 521 61, 523218, 523219, C08J 910, C08J 926, C08J 932

Patent

active

051681048

ABSTRACT:
A method to prepare uniform populations of macroscopic beads containing pores of at least 0.1 microns diameter is described. The beads consist essentially of a copolymer of a monoethylenically unsaturated monomer and a crosslinking polyethylenically unsaturated monomer, said resulting copolymer optionally being derivatized with functional groups, linking moieties, and/or affinity ligands. The macroporous beads are obtained by utilizing, as porogen in the polymerization reaction, porous inorganic particles which have been preabsorbed with a blowing agent. The blowing agent is not activated until after the polymerization takes place; when the blowing agent is activated, the organic polymer which isolates the inorganic porogen particles from each other in the bead is destroyed. Upon subsequent dissolution of the inorganic porogen, a network of pores throughout the organic copolymer-formed particle is formed. The resulting beads are useful in a variety of chromatographic, analytical and biomedical techniques.

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