Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1988-10-14
1990-06-26
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514667, A61K 3113
Patent
active
049372696
ABSTRACT:
Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are substituted alkyl (C.sub.2 -C.sub.6) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R.sub.3 and R.sub.4 are alkyl or substituted alkyl (C.sub.1 -C.sub.6), and n=2 to about 6. Preferably R.sub.1 through R.sub.4 are the same and are 2-hydroxyalkyl.
REFERENCES:
patent: 2697118 (1954-12-01), Lundsted et al.
patent: 4035480 (1977-07-01), Green et al.
patent: 4290904 (1981-09-01), Poper et al.
patent: 4778825 (1988-10-01), Smith et al.
Chemical Abstracts, vol. 103, 1985, p. 40, Abstract 171653q.
Patel Sanjay R.
Rowland Edwin C.
Smith Daniel J.
Schenkman Leonard
University of Akron
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