Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1990-09-21
1993-06-15
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530380, 530413, C07G 700, C07K 1300, A61K 3702
Patent
active
052199916
ABSTRACT:
The present invention relates to a method of purifying macrophage stimulating protein (MSP) and to the highly purified MSP. The present invention further relates to antibodies to MSP. The highly purified MSP may be used for fighting pathogen infections.
REFERENCES:
patent: 4847325 (1989-07-01), Shadle et al.
Leonard et al., Exp. Cell Res., A serum protein that stimulates macrophage movement, chemotaxis and spreading, (1976), vol. 102, pp. 434-438.
Leonard et al., Exp. Cell Res., Isolation of Macrophage Stimulating Protein (MSP) from Human Serum, (1978), vol. 114, pp. 117-126.
Falk et al., Journal of the Immunological Methods, A 48-Well Micro Chemotaxis Assembly for Rapid and Accurate Measurement of Leukocyte Migration, vol. 33 (1980) pp. 239-247.
Leonard et al., Journal of the Reticuloendothelial Society, Effects of Cell Concentration on Chemotactic Responsiveness of Mouse Resident Peritoneal Macrophages, vol. 30, No. 4, (1981), pp. 271-282.
Ettore Appella
Leonard Edward J.
Skeel Alison H.
Teizo Yoshimura
Rucker Susan S.
The United States of America as represented by the Department of
Touzeau P. Lynn
Wityshyn Michael G.
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