Macrophage receptor with a collagenous domain

Details Macrophage receptor with a collagenous domain Macrophage receptor with a collagenous domain

1997-07-11

2000-05-16

Caputa, Anthony C

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

930 10, C07K 14705

Patent

active

060639016

ABSTRACT:
The present invention is directed to processes for isolating and identifying the nucleotide sequence of a gene for a novel macrophage receptor with collagenous structure, termed "MARCO". The new macrophage receptor with a collagenous domain binds gram positive and negative bacteria and acetylated LDL. Moreover, the invention relates to the nucleotide sequence for MARCO identified by the process of the invention and the isolated and purified polypeptide chain encoded by such a sequence.

REFERENCES:
Asheknas et al. "Structures and High and Low Affinity Ligand Binding Properties of Murine Type I and Type II Macrophage Scavenger Receptors"; Journal of Lipid Research; vol. 34, pp. 983-1000; 1993.
Krieger & Herz Ann. Rev. Biochem.; vol. 63, pp. 601-637; 1994.

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