Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1997-07-22
1999-11-16
LeGuyader, John L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530300, 530324, 530350, 536 231, 536 235, C07K 1400, C07K 500, C07K 1452
Patent
active
059860600
ABSTRACT:
The present invention relates to a human MIF-3 and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the polypeptide therapeutically for treating cancer, infections, acceleration of wound healing, stimulating the immune system, as an anti-inflammatory. Methods of using antibodies and antagonists for therapeutic purposes, is also disclosed, for example, for treating lethal endotoxaemia, ocular inflammation and diagnosing immune diseases. Also disclosed are diagnostic methods for detecting conditions related to a mutation in a nucleic acid sequence encoding a polypeptide of the present invention and altered levels of the polypeptide of the present invention.
REFERENCES:
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patent: 5650295 (1997-07-01), Li et al.
Hirose, S., et al., Microbiol. Immunol., 35:235-245 (1991).
Zeng, Fu-Yue et al., Archives of Biochem., 303:74-80 (1993).
Oki, S., et al., Lymphokine & Cytokine Research, 10:273-280 (1991).
Hochstrasser, D., et al., Electrophoresis, 13:992-101 (1992).
Lanahan, A., et al., Molecular & Cellular Biology, 12:3919-3929 (1992).
Bernhagen, J., et al., Letter to Nature, 365:756-759 (1993).
Wistow, G., et al., Proc. Natl. Acad. Sci., 90:1272-1275 (1993).
Weiser, W., et al., Proc. Natl. Acad. Sci. , 86:7522-7526 (1989).
GenBank Accession No.: U49785 (Mar. 5, 1997).
GenBank Accession No.: U84143 (Jan. 29, 1997).
Fitzgerald Lisa M.
Li Haodong
Brookes A. Anders
Human Genome Sciences Inc.
LeGuyader John L.
McGarry Sean
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