Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1997-11-18
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 53038824, 53038825, 435335, 435336, 435331, C07K 1622, C07K 1624, C07K 1626
Patent
active
056889275
ABSTRACT:
The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C--C chemokine designated MDC. Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein.
REFERENCES:
patent: 4965392 (1990-10-01), Fritzberg et al.
patent: 5037630 (1991-08-01), Fritzberg et al.
patent: 5179078 (1993-01-01), Rollins et al.
patent: 5241049 (1993-08-01), Goodman et al.
patent: 5278287 (1994-01-01), Rollins et al.
patent: 5413778 (1995-05-01), Kunkel et al.
Ahuja, et al., "Molecular Evolution of the Human Interleukin-8 Receptor Gene Cluster," Nature Genetics, 2:31-36 (Sep., 1992).
Altschul, et al., "Basic Local Alignment Search Tool," J. Mol. Biol., 215:403-410 (1990).
Baggiolini, et al., "Interleukin-8 and Related Chemotactic Cytokines--CXC and CC Chemokines," Advances in Immunology, 55:97-179 (1994).
Better et al., "Escherichia coli Secretion of an Active Chimeric Antibody Fragment," Science, 240:1041-43 (May 20, 1988).
Bitter, et al., "Secretion of foreign proteins from Saccharomyces cerevisiae directed by .alpha.-factor gene fusions," Proc. Natl. Acad. Sci. USA, 81:5330-5334 (Sep., 1984).
Brown, et al., "A Family of Small Inducible Proteins Secreted by Leukocytes are Members of a New Superfamily that Includes Leukocyte and Fibroblast-Derived Inflammatory Agents, Growth factors, and Indicators of Various Activation Processes," J. Immunology, 142(2):679-687 (Jan. 15, 1989).
Chang, et al., "Cloning and expression of a .lambda.-interferon-inducible gene in monocytes: a new member of a cytokine gene family," International Immunology, 1(4):388-397 (1989).
Chang, "Thrombin Specificity," Eur. J. Biochem., 151:217-224 (1985).
Charo, et al., "Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails," Proc. Natl. Acad. Sci., USA, vol. 91:2752-2756 (Mar., 1994).
"Chemokines" in R&D Systems 1995 Catalog, R&D Systems, Minneapolis, MN pp. 80-85.
Chen et al., "High-Efficiency Transformation of Mammalian Cells by Plasmid DNA," Mol. Cell. Biol., 7(8):2745-2752 (Aug. 1987).
Chen, et al., "Calcium Phosphate-Medicated Gene Transfer: A Highly Efficient Transfection System for Stably Transforming Cells with Plasmid DNA," BioTechniques, 6(7):632-638 (1988).
Clark-Lewis, et al., "Structure-Activity Relationships of Interleukin-8 Determined Using Chemically Synthesized Analogs," J. Biol. Chem., 266(34):23128-23134 (Dec. 5, 1991).
Danoff, et al., "Cloning, Geonomic Organization, and Chromosomal Localization of the Scya5 Gene Encoding the Murine Chemokine RANTES," J. Immunology, 152:1182-1189 (1994).
Devi et al., "Biologic Activities of the beta-chemokine TCA3 on neutrophils and macrophages," J. Immunol. 154(10):5376-83 (1995).
Dunlop, et al., "Demonstration of Stem Cell Inhibition and Myeloprotective Effects of SCI/rhMIP1 .alpha. In Vivo," Blood, 79(9):2221-2225 (May 1, 1992).
Elstad, et al., "Synthesis and Release of Platelet-Activating Factor by Stimulated Human Mononuclear Phagocytes," J. Immunology, 140(5):1618-1624 (Mar. 1, 1988).
Fowlkes et al., "Multipurpose Vectors for Peptide Expression on the M13 Viral Surface," BioTechniques, 13(3):422-427 (1992).
Gao, et al., "Structure and Functional Expression of the Human Macrophage Inflammatory Protein 1.alpha./Rantes Receptor," J. Exp. Med., 177:1421-1427 (May, 1993).
Gerard, et al., "Human Chemotaxis Receptor Genes Cluster at 19q13.3-13.4. Characterization of the Human C5a Receptor Gene," Biochemistry, 32:1243-1250 (1993).
Gray, "Inflammatory Bowel Disease," in Scientific American Medicine, Dale & Federman (Eds.), New York: Scientific American, Inc., vol. 1, Chapter 4, Part IV, pp. 10-16 (1991).
Harada, et al., "Essential involvement of interleukin-8 (IL-8) in acute inflammation," J. Leukocyte Biology, 56:559-564 (Nov. 1994).
Holmes et al., "Structure and Functional Expression of a Human Interleukin-8 Receptor," Science, 253:1278-80 (Sep. 13, 1991).
Horuk, et al., "Purification, Receptor Binding Analysis, and Biological Characterization of Human Melanoma Growth Stimulating Activity (MGSA)," J. Biol. Chem., 268(1):541-546 (Jan. 5, 1993).
Kelvin, et al., "Chemokines and Serpentines: The Molecular Biology of Chemokine Receptors," J. Leukocyte Biology, 54:604-612 (Dec., 1993).
Kuna, et al., "Rantes, A Monocyte and T Lymphocyte Chemotatic Cytokine Releases Histamine From Human Basophils," J. Immunology, 149(2):636-642 (Jul. 15, 1992).
Kurjan, et al., "Structure of a Yeast Pheromone Gene (MF.alpha.): A Putative-.alpha.-Factor Precursor Contains Four Tandem Copies of Mature .alpha.-Factor," Cell, 30:933-943 (Oct., 1992).
Laning, et al., "Inhibition of In Vivo Tumor Growth by the .beta. Chemokine, TCA3," J. Immunology, 153:4625-4635 (1994).
Luo, et al., "Biologic Activities of the Murine .beta.-Chemokine TCA3," J. Immunology, 153:4616-4624 (1994).
Matsushima, et al., "Purification and Characterization of a Novel Monocyte Chemotactic and Activating Factor Produced by a Human Myelomonocytic Cell Line," J. Exp. Med., 169:1485-1490 (Apr. 1989).
Maze, et al., "Myelosuppressive Effects in Vivo of Purified Recombinant Murine Macrophage Inflammatory Protein-1.alpha.," J. Immunology, 149(3):1004-1009 (Aug. 1, 1992).
Meurer, et al., "Formation of Eosinophilic and Monocytic Intradermal Inflammatory Sites in the Dog by Injection of Human RANTES but not Human Monocyte Chemoattractant Protein 1, Human Macrophage Inflammatory Protein 1.alpha., or Human Interleukin 8," J. Exp. Med. 178:1913-1921 (Dec., 1993).
Miller, et al., "A Novel Polypeptide Secreted By Activated Human T Lymphocytes," J. Immunology, 143(9):2907-2916 (Nov. 1, 1989).
Murphy, et al., "Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor," Science, 253:1280-83 (Sep. 13, 1991).
Nakao, et al., "Structures of Human Genes Coding for Cytokine LD78 and Their Expression," Molecular and Cellular Biology, 10(7):3646-3658 (Jul., 1990).
Neote et al., "Molecular Cloning, Functional Expression, and Signaling Characteristics of a C-C Chemokine Receptor," Cell, 72:415-425 (Feb. 12, 1993).
Perussia, et al., "Terminal Differentiation Surface Antigens of Myelomonocytic Cells are Expressed in Human Promyelocytic Leukemia Cells (HL60) Treated with Chemical Inducers," Blood, 58(4):836-843 (Oct., 1981).
Picker, et al., "Physiological and Molecular Mechanisms of Lymphocyte Homing," Annu. Rev. Immunol., 10:561-91 (1992).
Price, et al., "Expression, purification and characterization of recombinant murine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast,"Gene, 55:287-293 (1987).
Rose, et al., "Propagation and Expression of Cloned Genes in Yeast: 2-.mu.m Circle-Based Vectors," Methods in Enzymology, 185:234-279 (1990).
Sambrook et al., Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory (1989), pp. 6.1-6.35, 1.74-1.84, 1.90-1.104.
Sarris, et al., "Human Interferon-inducible Protein 10: Expressed and Purification of recombinant Protein Demonstrate Inhibition of Early Human Hematopoietic Progenitors," J. Exp. Med., 178:1127-1132 (Sep., 1993).
Schall, et al., "A Human T Cell-Specific Molecule is a Member of a New Gene Family," J. Immunology, 141(3):1018-1025 (Aug. 1, 1988).
Springer, "Traffic Signals for Lymphocyte Recirculation and Leukocyte Emigration: The Multistep Paradigm," Cell, 76:301-314 (Jan. 28, 1994).
Stafforini, et al., "Human Macrophages Secrete Platelet-activating Factor Acetylhydrolase," J. Biol. Chem., 265(17):9682-9687 (Jun. 15, 1990).
Stearns, et al., "Manipulating Yeast Genome Using Plasmid Vectors," Methods in Enzymology, 185:280-297 (1990).
Taub, et al., "Chemokines, inflammation and the immune system," Therapeutic Immunology, 1:229-246 (1994).
Tjoelker, et al., "Anti-inflammatory Properties of a Platelet-Activating Factor Aceytlhydrolase," Nature 374:549-553 (Apr. 6, 1995).
Van Damme, et al., "Structural and Functional Identification of Two Human, Tumor-derived Monocyte Chemotactic Proteins (MCP-2 an
Godiska Ronald
Gray Patrick W.
Eisenschenk Frank C.
ICOS Corporation
LandOfFree
Macrophage derived chemokine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Macrophage derived chemokine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrophage derived chemokine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1566753