Macromolecules for sealing capillary endothelial junctions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 59, 514921, 514950, A61K 3100

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active

049944444

ABSTRACT:
The present invention provides compositions of matter and methods for treating a human subject to prevent leakage of serum albumin from capillary endothelial junctions during a period of increased capillary permeability. The method comprises administering to the human subject an effective capillary pore sealing amount of a macromolecule which is biodegradable, non-toxic, globular in shape, with a molecular weight range from about 100,000 daltons to about 1,000,000 daltons and a pharmaceutically acceptable carrier. The composition of matter comprises a fraction derived from hydroxyethyl starch.

REFERENCES:
patent: 3523938 (1970-08-01), Hershenson et al.
patent: 3758382 (1973-09-01), Knorpp
patent: 4798824 (1989-01-01), Belzer et al.
Joris, et al. (1972) Virchows Arc, 12:73-83 (Exhibit A).
Horan, et al. (1986) American Journal of Pathology, 124:570-576 (Exhibit B).
Majno, et al. (1961) J. Biophys. Biochem. Cytol, 11:571-605 (Exhibit C).
Lelcuk, et al. (1985) Ann. Surg., 202:642-646 (Exhibit D).
Joris, et al. (1987) i Am. J. of Pathology, 126:19-24 (Exhibit E).
Grega, et al. (1986) Fed.Proc., 45:75-76 (Exhibit F).
Maier, R. V., and Carrico, C. J. (1986) Developments in Resuscitation Advances in Surgery, 19:290 (Exhibit G).
Moggio, R. A. et al. (1983), Crit. Care Med., 11:943 (Exhibit H).
Kirklin, J. K. et al. (1984) Ann. Thorac. Surg., 37:40 (Exhibit I).
Diehl, H. T. et al. (1982) Ann. Thorac. Surg., 34:674 (Exhibit J).
Rackow, E. C. et al. (1983) Crit. Care Med., 11:839 (Exhibit K).
Puri, V. K. et al. (1982) Crit. Care Med., 10:230 (Exhibit L).
Ring J., and Messmer K. (1977) Lancet 1:466 (Exhibit M).

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