Macromolecule sequencing packet and method of use

Details Macromolecule sequencing packet and method of use Macromolecule sequencing packet and method of use

1996-07-31

1999-07-13

Alexander, Lyle A.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

436178, 435 6, 428 641, 428405, 428406, 428407, G01N 33545

Patent

active

059226080

ABSTRACT:
A method, apparatus and article for sequencing polypeptides and proteins ("macromolecules") utilizes a sequencing packet comprised of a plurality of substrates having two different derivatization chemistries within a forarninous container. The sequencing packet is disposed within a reaction chamber in a cartridge assembly having an inlet and outlet. An unknown target macromolecule, and preferably a control macromolecule are bonded to the substrates. The macromolecule and control are then simultaneously sequenced. The control serves to monitor the efficacy of the sequencing process.

REFERENCES:
patent: 4631211 (1986-12-01), Houghten
patent: 5137765 (1992-08-01), Farnsworth
System 6300/Gold High Performance Amino Acid Analyzers Price List, Beckman Instruments, Inc., Sep. 1993.
Productivity Multiplies with TriCart, Beckman Instruments, Inc., 1992.
TriCart Productivity Comparison, Beckman Instruments, inc., 1993.
Brochure entitled The LF 3000 Protein Sequencer, Beckman Instruments, Inc., 1993.

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