Macromolecular platinum antitumor compounds

Details Macromolecular platinum antitumor compounds Macromolecular platinum antitumor compounds

1987-02-25

1988-12-27

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 8591, 514 54, 514 58, 436548, 556137, C07F 1500

Patent

active

047939869

ABSTRACT:
A composition comprising a pharmaceutically acceptable polysaccharide carrier which has been chemically activated and then linked to platinum in either a +2 or +4 oxidation state through a bidentate oxygen-containing ligand including an amine group coupled to the activated polysaccharide. The composition may be used to link platinum metal remotely to a monoclonal antibody via the oxygen-containing ligand and the polysaccharide carrier such as dextran. The composition is optionally radiolabeled.

REFERENCES:
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4584392 (1986-04-01), Smith et al.
patent: 4614811 (1986-09-01), Gandolfi
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4673754 (1987-06-01), Smith et al.
Neoplasma, 33, 6 (1986) pp. 665-670.
Inorganica Chimica Acta, 135 (1987) 27-31.

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