Macromolecular mitomycin C derivative and method for production

Details Macromolecular mitomycin C derivative and method for production Macromolecular mitomycin C derivative and method for production

1992-03-12

1993-10-12

Carrillo, Ana L.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525178, 525937, C08L 7700

Patent

active

052526739

ABSTRACT:
A macromolecular mitomycin derivative excellent in antitumor ability is produced by causing a specific divinyl ether-maleic anhydride copolymer to react with a specific aminocarboxylic acid and causing mitomycin C to react on the resultant reaction product. The derivative is optionally converted into a pharmacologically acceptable salt.

REFERENCES:
patent: 4520162 (1985-05-01), Hirano et al.
Cancer Research vol. 34, Mar. 1974 pp. 506-511 Page S. Morahan, et al: Antitumor Action of Pyran Copolymer and Tilorone Against Lewis Lung Carcinoma and B-16 Melanoma.
Cancer Treatment Reports vol. 62, No. 11, Nov. 1978 pp. 1791-1796, Robert L. Stolfi, et al: Therapeutic Activity of Maleic Anhydride-Vinyl Ether Copolymers Against Spontaneous, Autochthonous Muring Mammary Tumors.
Cancer Research 41, Oct. 1981, pp. 3901-3907. Scott E. Loveless, et al: Maleic Vinyl Ether Murine Macrophages Against Lung-Metastasizing Tumors.

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