Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1996-08-19
2000-07-18
Degen, Nancy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
436523, 436528, 530350, 530402, 530812, C07K 1702, C07K 100, C08H 102, G01N 33544
Patent
active
060909250
ABSTRACT:
Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
REFERENCES:
patent: Re33670 (1991-08-01), Maglio
patent: Re35862 (1998-07-01), Steiner et al.
patent: 2489763 (1949-11-01), Dunne
patent: 2628227 (1953-02-01), Ames
patent: 2831767 (1958-04-01), Dann et al.
patent: 3088875 (1963-05-01), Fisk
patent: 3089818 (1963-05-01), Stone
patent: 3137631 (1964-06-01), Soloway
patent: 3242051 (1966-03-01), Hiestand et al.
patent: 3317434 (1967-05-01), Veis et al.
patent: 3336155 (1967-08-01), Rowe
patent: 3341466 (1967-09-01), Brynko et al.
patent: 3407076 (1968-10-01), Ganz
patent: 3510435 (1970-05-01), Sirine
patent: 3616229 (1971-10-01), Wildi et al.
patent: 3619371 (1971-11-01), Crook et al.
patent: 3663687 (1972-05-01), Evans
patent: 3664963 (1972-05-01), Pasin
patent: 3679653 (1972-07-01), Schuck et al.
patent: 3691090 (1972-09-01), Kitajima et al.
patent: 3694372 (1972-09-01), Anderson et al.
patent: 3703474 (1972-11-01), Huber
patent: 3743604 (1973-07-01), Schnoring et al.
patent: 3764477 (1973-10-01), Klaus et al.
patent: 3775253 (1973-11-01), Dieter et al.
patent: 3775378 (1973-11-01), Dahlmans et al.
patent: 3838007 (1974-09-01), van Velzen
patent: 3857931 (1974-12-01), Hager
patent: 3871888 (1975-03-01), Michel-Wolwertz et al.
patent: 3871964 (1975-03-01), Huper et al.
patent: 3872024 (1975-03-01), Horger
patent: 3887699 (1975-06-01), Yolles
patent: 3909444 (1975-09-01), Anderson et al.
patent: 3937668 (1976-02-01), Zolle
patent: 3941756 (1976-03-01), Huper et al.
patent: 4011205 (1977-03-01), Dean et al.
patent: 4035316 (1977-07-01), Yen et al.
patent: 4038140 (1977-07-01), Jaworek et al.
patent: 4039413 (1977-08-01), Kraemer et al.
patent: 4046722 (1977-09-01), Rowland
patent: 4061466 (1977-12-01), Sjoholm et al.
patent: 4064080 (1977-12-01), Daniel
patent: 4070348 (1978-01-01), Kraemer et al.
patent: 4094744 (1978-06-01), Hartdegen et al.
patent: 4105598 (1978-08-01), Yen et al.
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4115534 (1978-09-01), Ithakissios
patent: 4116949 (1978-09-01), Goodman et al.
patent: 4118349 (1978-10-01), Bonacker et al.
patent: 4138356 (1979-02-01), Vincent et al.
patent: 4138383 (1979-02-01), Rembaum et al.
patent: 4144050 (1979-03-01), Frensch et al.
patent: 4147767 (1979-04-01), Yapel, Jr.
patent: 4157437 (1979-06-01), Okuzumi et al.
patent: 4166105 (1979-08-01), Hirschfeld
patent: 4169804 (1979-10-01), Yapel
patent: 4181636 (1980-01-01), Fischer
patent: 4184986 (1980-01-01), Krasnobajew et al.
patent: 4210723 (1980-07-01), Dorman et al.
patent: 4224198 (1980-09-01), Rembaum et al.
patent: 4256737 (1981-03-01), Nestor et al.
patent: 4267234 (1981-05-01), Rembaum
patent: 4267235 (1981-05-01), Rembaum et al.
patent: 4277364 (1981-07-01), Shasha et al.
patent: 4322311 (1982-03-01), Lim et al.
patent: 4326008 (1982-04-01), Rembaum
patent: 4344857 (1982-08-01), Shasha et al.
patent: 4349530 (1982-09-01), Royer
patent: 4353962 (1982-10-01), Himel et al.
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4359377 (1982-11-01), Blanc et al.
patent: 4377567 (1983-03-01), Geho
patent: 4382813 (1983-05-01), Shasha
patent: 4389330 (1983-06-01), Tice et al.
patent: 4391309 (1983-07-01), Steiner
patent: 4407957 (1983-10-01), Lim
patent: 4421896 (1983-12-01), Dorman
patent: 4438239 (1984-03-01), Rembaum et al.
patent: 4439488 (1984-03-01), Trimnell et al.
patent: 4460722 (1984-07-01), Igarashi et al.
patent: 4472382 (1984-09-01), Labrie et al.
patent: 4482606 (1984-11-01), Bousquet et al.
patent: 4490407 (1984-12-01), Lafon
patent: 4495288 (1985-01-01), Jarvis, Jr. et al.
patent: 4496689 (1985-01-01), Mitra
patent: 4511694 (1985-04-01), Kramer et al.
patent: 4522812 (1985-06-01), Koguchi et al.
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4530840 (1985-07-01), Tice et al.
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 4552812 (1985-11-01), Margel et al.
patent: 4590068 (1986-05-01), Berthet et al.
patent: 4605550 (1986-08-01), Trill
patent: 4606940 (1986-08-01), Frank et al.
patent: 4608277 (1986-08-01), Greiner et al.
patent: 4608278 (1986-08-01), Frank et al.
patent: 4609707 (1986-09-01), Nowinski et al.
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4617186 (1986-10-01), Schafer et al.
patent: 4622244 (1986-11-01), Lapka et al.
patent: 4622362 (1986-11-01), Rembaum
patent: 4637480 (1987-01-01), Obrecht et al.
patent: 4642111 (1987-02-01), Sakamoto et al.
patent: 4645664 (1987-02-01), Lange
patent: 4652441 (1987-03-01), Okada et al.
patent: 4666641 (1987-05-01), Fickat et al.
patent: 4671954 (1987-06-01), Goldberg et al.
patent: 4674480 (1987-06-01), Lemelson
patent: 4675189 (1987-06-01), Kent et al.
patent: 4677191 (1987-06-01), Tanaka et al.
patent: 4690906 (1987-09-01), Duheille et al.
patent: 4708816 (1987-11-01), Chang et al.
patent: 4713249 (1987-12-01), Schroder
patent: 4727064 (1988-02-01), Pitha
patent: 4728640 (1988-03-01), Labrie et al.
patent: 4728721 (1988-03-01), Yamamoto et al.
patent: 4741872 (1988-05-01), De Luca et al.
patent: 4743545 (1988-05-01), Torobin
patent: 4743589 (1988-05-01), Labrie et al.
patent: 4744178 (1988-05-01), Afshar
patent: 4745102 (1988-05-01), Labrie et al.
patent: 4752638 (1988-06-01), Nowinski et al.
patent: 4761398 (1988-08-01), Edens et al.
patent: 4764467 (1988-08-01), Goertz et al.
patent: 4766012 (1988-08-01), Valenti
patent: 4775660 (1988-10-01), Labrie et al.
patent: 4777089 (1988-10-01), Takizawa et al.
patent: 4783335 (1988-11-01), Lipshitz
patent: 4783336 (1988-11-01), Margel et al.
patent: 4794000 (1988-12-01), Ecanow
patent: 4795641 (1989-01-01), Kashdan
patent: 4801529 (1989-01-01), Perlman
patent: 4812445 (1989-03-01), Eden et al.
patent: 4818542 (1989-04-01), DeLuca et al.
patent: 4822534 (1989-04-01), Lencki et al.
patent: 4822535 (1989-04-01), Ekman et al.
patent: 4824678 (1989-04-01), Lindahl et al.
patent: 4826689 (1989-05-01), Violanto et al.
patent: 4832686 (1989-05-01), Anderson
patent: 4849228 (1989-07-01), Yamamoto et al.
patent: 4851386 (1989-07-01), Labrie et al.
patent: 4853226 (1989-08-01), Machida et al.
patent: 4863729 (1989-09-01), Zuckerkandl
patent: 4863972 (1989-09-01), Itagaki et al.
patent: 4865846 (1989-09-01), Kaufman
patent: 4865850 (1989-09-01), Shell et al.
patent: 4871716 (1989-10-01), Longo et al.
patent: 4882166 (1989-11-01), Graham et al.
patent: 4895724 (1990-01-01), Cardinal et al.
patent: 4897267 (1990-01-01), Bontemps et al.
patent: 4897268 (1990-01-01), Tice et al.
patent: 4904479 (1990-02-01), Illum
patent: 4904592 (1990-02-01), Freeman et al.
patent: 4906488 (1990-03-01), Pera
patent: 4908233 (1990-03-01), Takizawa et al.
patent: 4911952 (1990-03-01), Doane et al.
patent: 4913908 (1990-04-01), Couvreur et al.
patent: 4917893 (1990-04-01), Okada et al.
patent: 4923645 (1990-05-01), Tsang et al.
patent: 4925673 (1990-05-01), Steiner et al.
patent: 4925677 (1990-05-01), Feijen
patent: 4931284 (1990-06-01), Ekman et al.
patent: 4931362 (1990-06-01), Zsifkovits et al.
patent: 4933185 (1990-06-01), Wheatley et al.
patent: 4935172 (1990-06-01), Ishiguro et al.
patent: 4938797 (1990-07-01), Hasslin et al.
patent: 4938900 (1990-07-01), Moriwaki et al.
patent: 4954298 (1990-09-01), Yamamoto et al.
patent: 4956129 (1990-09-01), Scher et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 4963526 (1990-10-01), Ecanow
patent: 4970031 (1990-11-01), Gotoh
patent: 4973469 (1990-11-01), Mulligan et al.
patent: 4981842 (1991-01-01), Labrie et al.
patent: 4985064 (1991-01
Blizzard Charles D.
Brown Larry R.
Di Jie
Scott Terrence L.
Sudhalter Judith
Degen Nancy
Epic Therapeutics, Inc.
LandOfFree
Macromolecular microparticles and methods of production and use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Macromolecular microparticles and methods of production and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macromolecular microparticles and methods of production and use will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2038116