Macromolecular environment control in specific receptor assays

Details Macromolecular environment control in specific receptor assays Macromolecular environment control in specific receptor assays

1978-11-24

1981-06-23

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

23230B, 424 12, 435177, 435178, 435810, 435 6, B12Q 166, C12N 1102, C12N 1110

Patent

active

042751497

ABSTRACT:
Method and compositions are provided for performing protein binding assays involving a homologous pair consisting of ligand and receptor for the ligand. The method employs a label conjugated to a member of said homologous pair and a uniformly dispersed discontinuous phase of discrete particles in a continuous aqueous phase, where the discrete particles create microenvironments which allow for discrimination between the label associated with the particle--in a discontinuous phase--and the label in the continuous phase.
Various conjugates and particles are provided which find use in the subject method.

REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 4052010 (1977-10-01), Baker et al.
patent: 4059685 (1977-11-01), Johnson
patent: 4067959 (1978-01-01), Bolz
patent: 4134792 (1979-01-01), Boguslaski et al.
patent: 4193983 (1980-03-01), Ullman et al.
Wingard, et al., Applied Biochemistry and Bioengineering, vol. 1, Academic Press, NY, (1976), pp. 135-138.

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