Macromolecular coordination compound containing platinum with an

Details Macromolecular coordination compound containing platinum with an Macromolecular coordination compound containing platinum with an

1985-11-08

1987-04-21

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

046598499

ABSTRACT:
A macromolecular compound with antitumor activity in which hydroxy groups in side chains of a polymer have the character of primary, secondary or tertiary alcohols and are completely or in part esterified with carboxyl in the position C4 of 1,2,4-tricarboxybenzene, whereas the carboxyls in positions C1 and C2 bind an atom of platinum with coordination bonded amino ligands.
A method for producing the macromolecular compound consists in acylation of the polymer carrying alcohol groups with chloride anhydride of trimellitic acid of the formula II, ##STR1## hydrolyzing the anhydride in the subsequent step, and bonding an atom of bivalent platinum carrying an amino ligand to the formed vicinal carboxylic groups.

REFERENCES:
patent: 4283342 (1981-08-01), Yolles
patent: 4376782 (1983-03-01), Turkevich et al.
patent: 4551502 (1985-11-01), Howell et al.
patent: 4565884 (1986-01-01), Andrulis, Jr. et al.
patent: 4584392 (1986-04-01), Smith et al.

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