Macromolecular arrays on polymeric brushes and methods for...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S091500, C525S050000, C525S055000, C525S326100, C525S330300

Reexamination Certificate

active

06994964

ABSTRACT:
Polymeric brush substrates and methods for their preparation are provided. Methods are also provided for preparing macromolecular arrays on such polymeric brush substrates. Using polymeric brush substrates allows control over functional site density as well as wettability and porosity of the substrate. These polymeric brushes are useful in solid-phase synthesis of arrays of peptides, polynucleotides or small organic molecules.

REFERENCES:
patent: 4581429 (1986-04-01), Solomon et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5242974 (1993-09-01), Holmes
patent: 5288514 (1994-02-01), Ellman
patent: 5312871 (1994-05-01), Mardare et al.
patent: 5324663 (1994-06-01), Lowe
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5451683 (1995-09-01), Barrett et al.
patent: 5482867 (1996-01-01), Barrett et al.
patent: 5489678 (1996-02-01), Fodor et al.
patent: 5491074 (1996-02-01), Aldwin et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5512131 (1996-04-01), Kumar et al.
patent: 5527681 (1996-06-01), Holmes
patent: 5550215 (1996-08-01), Holmes
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5571639 (1996-11-01), Hubbell et al.
patent: 5593839 (1997-01-01), Hubbell et al.
patent: 5599695 (1997-02-01), Pease et al.
patent: 5624711 (1997-04-01), Sundberg et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5639603 (1997-06-01), Dower et al.
patent: 5677195 (1997-10-01), Winkler et al.
patent: 5677388 (1997-10-01), Koster et al.
patent: 5708102 (1998-01-01), Fryd et al.
patent: 5728747 (1998-03-01), Kazmaier et al.
patent: 5744101 (1998-04-01), Fodor et al.
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5753788 (1998-05-01), Fodor et al.
patent: 5770456 (1998-06-01), Holmes
patent: 5773571 (1998-06-01), Nielsen et al.
patent: 5786461 (1998-07-01), Buchardt et al.
patent: 5807937 (1998-09-01), Matyjaszewski et al.
patent: 5831070 (1998-11-01), Pease et al.
patent: 5843655 (1998-12-01), McGall
patent: 5852129 (1998-12-01), Kusakabe et al.
patent: 5856011 (1999-01-01), Sogabe
patent: 6022963 (2000-02-01), McGall et al.
patent: 6413587 (2002-07-01), Hawker et al.
patent: 2002/0001845 (2002-01-01), Klaerner et al.
patent: H2-34479 (1990-02-01), None
patent: H3-99702 (1991-04-01), None
patent: 11-263819 (1999-09-01), None
patent: 2002-513668 (2002-05-01), None
patent: WO 92/20702 (1992-11-01), None
patent: WO 99/06425 (1999-02-01), None
patent: WO 99/57581 (1999-11-01), None
patent: WO 00/43539 (2000-07-01), None
patent: WO 00/61282 (2000-10-01), None
Mrksich et al., TIBTECH Jun. 1995, vol. 13, pp. 228-235.
Georges et al., “Narrow Molecular Weight Resins by a Free-Radical Polymerization Process,”Macromolecules, 26:2987-2988 (May 24, 1993).
Greszta et al., ““Living” Radical Polymerization. 1. Possibilities and Limitations,”Macromolecules, 27:638-644 (Jan. 31, 1994).
Hawker, “Molecular Weight Control by a ‘Living’ Free-Radical Polymerization Process,”J. Am. Chem. Soc., 116:11185-11186 (1994).
Hiltunen et al., “Effect of Catalyst and Polymerization Conditions on the Preparation of Low Molecular Weight Lactic Acid Polymers,”Macromolecules, 30:373-379 (Feb. 10, 1997).
Huang and Wirth, “Surface-Initiated Radical Polymerization on Porous Silica,”Analytical Chemistry, 69:4577-4580 (Nov. 15, 1997).
Husseman et al., “Controlled Synthesis of Polymer Brushes by “Living” Free Radical Polymerization Techniques,”Macromolecules, 32:1424-1431 (Mar. 9, 1999).
Kobayashi et al., “Silane Coupling Agent Having Dithiocarbamate Group for Photographfting of Sodium Styrene Sulfonate on Glass Surface,”J. Appl. Poly. Sci., 49:447-423 (Jul. 15, 1993).
Lee et al., “Polymerization of Vinyl Monomers Initiated by Chromium(II)Acetate+Organic Peroxides,”J. Chem. Soc. Trans. Faraday Soc. I, 74:1726 (1978).
McGall et al., “The Efficiency of Light-Directed Synthesis of DNA Arrays on Glass Substrates,”J. Am. Chem. Soc., 119:5081-5090 (Jun. 4, 1997).
Prucker and Rühe, “Synthesis of Poly(styrene) Monolayers Attached to High Surface Area Silica Gels through Self-Assembled Monolayers of Azo Initiators,”Macromolecules, 31:592-601 (1998).
Prucker and Ruehe, “Grafting of polymers to microparticulate silica by using immobilized azo initiators,”Macromolecular Chemistry II, University Bayreuth,Trans. Mater. Res. Soc. Jpn.15A:529-532 (1994).
Tovar et al., “Patterning molecularly thin films of polymers—new methods for photolithographic structuring of surfaces,”Supramol. Sci., 2(2):89-98 (1995).
Yamamoto et al., “Preparation of well-defined polymer brushes on silicon substrate by the surface-initiated ATRP technique and their characterization,”Polym. Prepr.(Am. chem. Sc., Div. Polym. Chem.) 40(2):401-402 (1999).
Young and Davis, “Efficient Isolation of Genes by Using Antibody Probes,”Proc. Natl. Acad. Sci. U.S.A., 80:1194-1198 (Mar. 1983).
Biesalski and Rühe, “Preparation and Characterization of a Polyelectrolyte Monolayer Covalently Attached to a Planar Solid Surface,”Macromolecules, 32:2309-2316 (Apr. 6, 1999).
Chang and Frank, “Grafting of Poly(γ-benzyl-L-glutamate) on Chemically Modified Silicon Oxide Surfaces,”Langmuir, 12:5824-5829 (Nov. 12, 1996).
Chang and Frank, “Vapor Deposition-Polymerization of α-Amino Acid N-Carboxy Anhydride on the Silicon(100) Native Oxide Surface,”Langmuir, 14:326-334 (Jan. 20, 1998).
English abstract of JP 11-263819.
English abstract of JP 2002-513668.
English abstract of JP H2-34479.
English abstract of JP H3-99702.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Macromolecular arrays on polymeric brushes and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Macromolecular arrays on polymeric brushes and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macromolecular arrays on polymeric brushes and methods for... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3709540

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.