Macrolides with anti-inflammatory activity

Details Macrolides with anti-inflammatory activity Macrolides with anti-inflammatory activity

2006-01-13

2011-12-20

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S007400

Reexamination Certificate

active

08080529

ABSTRACT:
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4″ position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.

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Culic et al., “Anti-Inflammatory effects of macrolide antibiotics,”European Journal of Pharmacology, V 429 N1-3, 2001, pp. 209-229.

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