Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-08-09
1997-03-11
Trinh, Ba K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549271, A61K 31335, C07D31300
Patent
active
056101783
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is hydroxy, 2-hydroxyethoxy, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkanoyloxy, halogen, amino, azido, a keto, p-nitrobenzenesulfonyl or a pyranyloxy group of the formula ##STR2## wherein X is a group of the formula ##STR3## wherein R.sub.3 is hydroxy, C.sub.1 -C.sub.4 alkanoyloxy or organic sulfonyloxy, and
REFERENCES:
Drose, S., et al., "Inhibitory Effect of Modified Balfilomycins and Concanamycins on P- and V-Type Adenosinetriphosphatases", Biochemistry, 32(15): 3902-3906 (1993).
Kinashi, H., et al., "Structure of Concanamycin A", Tetrahedron Letters, 22(39):3861-3864 (1981).
Kinashi, H., et al., "Isolation and Characterization of Concanamycins A, B and C", J. Antibiotics, 37(11):1333-1343, 1984.
Nakai, H. et al., Abstract, "Structure of Concanamycin A Pentahydrate", Acta Cryst., C48:1519-1521 (1992).
Westley, J. W., et al., "The Structure and Absolute Configureation of the 18-Membered Macrolide Lactone Antibiotic X-4357B (Concanamycin A)", J. Antibiotics, 37(12):1738-1740 (1984).
Woo, J-T., et al., "Isolation, Characterization and Biological Activities of Concanamycins as Inhibitors of Lysosomal Acidification", J. Antibiotics, 45(7):1108-1116 (1992).
Bindseil Kai U.
Boddien Claudia
Zeeck Axel
Ciba-Geigy Corporation
Elmer James Scott
Nowak Henry P.
Trinh Ba K.
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