Macrolide derivatives

Details Macrolide derivatives Macrolide derivatives

1984-07-12

1986-04-08

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, A61K 3171, C07H 1508

Patent

active

045813469

ABSTRACT:
C-8, 20-cyclo-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2'"-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, and Mycoplasma species, and pharmaceutical compositions thereof, are provided.

REFERENCES:
patent: 3178341 (1965-04-01), Hamill et al.
patent: 3326759 (1962-07-01), Hamill et al.
patent: 4345069 (1982-08-01), Sakakibara et al.
patent: 4385116 (1983-05-01), Baltz et al.
Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and Its Structure-Activity Relationship," Chem. Pharm. Bull. 30(1) 97-100 (1982).

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