Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1999-01-29
2000-07-18
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 77, 435 72, 514449, 536 65, C12N 120, C12P 1958, A01N 4302
Patent
active
060906103
ABSTRACT:
Compound 0406 having a chemical structural formula represented by the chemical formula (1) below and having an excellent immuno suppressive activity, and pharmaceutically acceptable salts thereof. ##STR1## (wherein R.sub.1 is --COCH.sub.2 COOH or H; R.sub.2 is --CO(CH.sub.2).sub.3 CH.sub.3 or --CO(CH.sub.2).sub.4 CH.sub.3 or H.)
REFERENCES:
Borel et al, "Biological Effects of Cyclosporin A: A New Antilymphyoctic Agent", Agents and Actions 6(4):468-475 (19976).
Kino et al, "FK-506, A Novel Immunosuppressant Isolated From a Streptomyces", J. Antibiotics XL(9):1249-1255 (1987).
Kumagai et al, "PC-766B, A New Macrolide Antibiotic Produced by Nocardia brasiliensis", J. Antibiotics 46(7):1139-1144 (1993).
Mikami et al, "Susceptibility Patterns of Pathogenic Nocardia to Some Selected Antimicrobial Agents and Their Usefulness in the Identification Work in a Clinical Laboratory", Bull. JFCC 5:89-95 (1989).
Shigemori et al, "Brasilinolide A, New Immunosuppressive Macrolide from Actinomycete Nocardia brasiliensis", Tetrahedron 52(27):9031-9034 (1996).
Kobayashi Jun'ichi
Komaki Hisayuki
Mikami Yuzuru
Tanaka Yasushi
Yazawa Katsukiyo
Higeta Shoyu Co. Ltd.
Lilling Herbert J.
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