Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-24
1999-12-21
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
435 77, 435872, 536 65, C12P 1958, A01N 4302
Patent
active
060049952
ABSTRACT:
Compound 0406 having a chemical structural formula represented by the chemical formula (1) below and having an excellent immuno suppressive activity, and pharmaceutically acceptable salts thereof. ##STR1## (wherein R.sub.1 is --COCH.sub.2 COOH or H; R.sub.2 is --CO(CH.sub.2).sub.3 CH.sub.3 or --CO(CH.sub.2).sub.4 CH.sub.3 or H.)
REFERENCES:
HCAPLUS ACS 1996:423691 (125:109799) Shigemori et al abstract of Tetrahedron (1996) 52(27), 9031-9034.
Borel, J.F. et al., "Biological effects of cyclosporin A: a new antilymphocytic agent.", Agents and Actions, vol. 6, No. 4, pp. 468-475 (1976).
Kino, Toru et al., "FK-506, A novel immunosuppressant isolated from a streptomyces.", The Journal of Antibiotics, vol. XL, No. 9, pp. 1249-1255 (1987).
Mikami, Yuzuru et al., "Susceptability patterns of pathogenic nocardia to some selected antimicrobial agents and their usefulness in the identification work in a clinical laboratory.", BULL JFCC, vol. 5, pp. 89-95 (1989).
Kobayashi Jun'ichi
Komaki Hisayuki
Mikami Yuzuru
Tanaka Yasushi
Yazawa Katsukiyo
Higeta Shoyu Co. Ltd.
Lilling Herbert J.
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