Macrolide compound

Details Macrolide compound Macrolide compound

2007-12-19

2011-12-06

Chandrakumar, Nizal (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S270000

Reexamination Certificate

active

08071793

ABSTRACT:
Disclosed are: a noveldinoflagellatealga; and a macrolide compound which can be used as a novel anticancer agent. Specifically disclosed is a macrolide compound produced by adinoflagellate Amphidiniumsp. Strain HYA002 or HYA0024. The macrolide compound has excellent proliferation-inhibiting effect against a human tumor cell and therefore can be used as a novel anticancer agent.

REFERENCES:
Kobayashi et al. Tetrahedron Letters, 27(47), 5755-5758, 1986.
Masashi Tsuda, et al., “Amphidinolide U, Novel 20-Membered Macrolide from Marine . . . ”, Tetrahedron 55, 1999, pp. 14565-14570, Elsevier Science Ltd.
Masashi Tsuda et al., “Iriometeolides -1b and -1c, 20-Membered Macrolides from a Marine . . . ”, Journal of Natural Products, 2007, pp. 1661-1663, American Chemical Society.
Junichi Kobayashi et al., “Amphidinolide-A, A Novel Antineoplastic Macrolide from the Marine . . . ”, Tetrahedron Letter, pp. 5755-5758, vol. 27, No. 47, Pergamon Journals, Ltd.
“Amphidinolides B6 and B7, Cytotoxic Macrolides . . . ” written by K. Oguchi et al. in Journal Of Natural Products, vol. 70, No. 10, 2007, pp. 1676-1679.
“Iriomoteolide-1 a, a Potent Cytotoxic 20-Membered Macrolide . . . ” written by M. Tsuda et al. in Journal Of Organic Chemistry, vol. 72, No. 12, 2007, pp. 4469-4474.
“Amphidinolides T2, T3, and T4, new 19-membered macrolides . . . ” written by Kobayashi Jun-Ichi et al. In Journal Of Organic Chemistry, vol. 66, No. 1,1, Jan. 2001, pp. 134-142.

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