Macrolide antibiotics, pharmaceutical compositions and methods o

Details Macrolide antibiotics, pharmaceutical compositions and methods o Macrolide antibiotics, pharmaceutical compositions and methods o

1984-03-26

1986-09-02

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, A61K 3171, C07H 1708

Patent

active

046096450

ABSTRACT:
Macrolides PTL-448 A and B, which can be prepared by aerobic cultivation of Streptomyces ambofaciens ATCC 15154 in the presence of a macrolide intermediate selected from protylonlide, 5-O-mycaminosylprotylonolide, 20-hydroxy-5-O-mycaminosylprotylonolide and 20-oxo-5-O-mycaminosylprotylonodide, and macrolides PTL-448 C and D, which can be prepared by acidic hydrolysis of PTL-448 A and B are useful antibiotics.

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patent: 4366247 (1982-12-01), Baltz et al.
patent: 4477443 (1984-10-01), Umezawa et al.
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Sadakane et al., "Jour. of Antibiotics", vol. XXXVI, 1983, pp. 921-922.
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