Macrolide antibiotic compounds

Details Macrolide antibiotic compounds Macrolide antibiotic compounds

1990-06-25

1992-12-08

Marx, Irene

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424120, 424121, 424122, 435119, 4352521, 4352535, C07D49322, A61K 3500, C12B 1718, C12N 120

Patent

active

051699567

ABSTRACT:
This invention relates to new agents designated LL-F28249.alpha., LL-F28249.beta., LL-F28249.gamma., LL-F28249.delta., LL-F28249.epsilon., LL-F28249.zeta., LL-F28249.eta., LL-F28249.theta., LL-F28249.iota., LL-F28249.kappa., LL-F28249.lambda., LL-F28249.mu., LL-F28249.nu., and LL-F2924.omega., to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. The present invention includes within its scope the biologically pure culture which produces there agents, derived from a newly-discovered and previously uncultured microorganism, Streptomyces cyaneogriseus subsp. noncyanogenus, NRRL 15773.

REFERENCES:
Carter, G. T., J. Org Chem, 1986, vol. 51, pp. 4264-4271.
Lardy, et al., Arch. Biochem. Biophys. vol. 78, 1958, pp. 487-497.

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