Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2008-05-13
2008-05-13
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
07371853
ABSTRACT:
The present invention is directed to compounds of formula (I)which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme in involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.
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Coburn et al., “Identification of a Small Molecule Nonpeptide Active Site Beta-Secretase Inhibitor That Displays a Nontraditional Binding Mode forAspartyl Proteases,” J. Med. Chem., vol. 47, pp. 6117-6119 (2004).
Coburn Craig A.
Stachel Shawn J.
Vacca Joseph P.
Jarrell Noble
Krovatin William
Merck & Co. , Inc.
Todaro John C.
Wilson James O.
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