Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2011-05-20
2011-12-20
Kifle, Bruck (Department: 1622)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
08080654
ABSTRACT:
The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections.
REFERENCES:
patent: 3480613 (1969-11-01), Walton
patent: 6323180 (2001-11-01), Llinas-Brunet et al.
patent: 6608027 (2003-08-01), Tsantrizos et al.
patent: 6777395 (2004-08-01), Bhat et al.
patent: 6955174 (2005-10-01), Friedrichs et al.
patent: 7470664 (2008-12-01), Holloway et al.
patent: 2002/0019363 (2002-02-01), Ismaili et al.
patent: 2002/0107138 (2002-08-01), Hoveyda et al.
patent: 2003/0236216 (2003-12-01), Devos et al.
patent: 2004/0006007 (2004-01-01), Gosselin et al.
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0067901 (2004-04-01), Bhat et al.
patent: 2004/0229776 (2004-11-01), Chen et al.
patent: 2004/0229818 (2004-11-01), Llinas-Brunet et al.
patent: 2004/0254159 (2004-12-01), Hasvold et al.
patent: 2004/0266668 (2004-12-01), Nakajima et al.
patent: 2005/0020503 (2005-01-01), Llinas-Brunet et al.
patent: 2005/0038240 (2005-02-01), Connolly et al.
patent: 2006/0257980 (2006-11-01), Li
patent: 2007/0027071 (2007-02-01), Holloway et al.
patent: 2010/0099695 (2010-04-01), Liverton et al.
patent: 1719773 (2006-11-01), None
patent: 2337262 (1999-11-01), None
patent: 2430621 (2007-04-01), None
patent: 97/41211 (1997-11-01), None
patent: 98/22496 (1998-05-01), None
patent: 98/46630 (1998-10-01), None
patent: 99/07733 (1999-02-01), None
patent: 99/07734 (1999-02-01), None
patent: 99/38888 (1999-08-01), None
patent: 99/43691 (1999-09-01), None
patent: 99/50230 (1999-10-01), None
patent: 99/64442 (1999-12-01), None
patent: 00/09543 (2000-02-01), None
patent: 00/09546 (2000-02-01), None
patent: 00/25780 (2000-05-01), None
patent: 00/59929 (2000-10-01), None
patent: 01/00622 (2001-01-01), None
patent: 01/47883 (2001-07-01), None
patent: 01/60379 (2001-08-01), None
patent: 01/68663 (2001-09-01), None
patent: 01/77091 (2001-10-01), None
patent: 01/77113 (2001-10-01), None
patent: 01/79246 (2001-10-01), None
patent: 01/90121 (2001-11-01), None
patent: 01/92282 (2001-12-01), None
patent: 02/04425 (2002-01-01), None
patent: 02/06246 (2002-01-01), None
patent: 02/18404 (2002-03-01), None
patent: 02/20497 (2002-03-01), None
patent: 02/32920 (2002-04-01), None
patent: 02/48116 (2002-06-01), None
patent: 02/48165 (2002-06-01), None
patent: 02/48172 (2002-06-01), None
patent: 02/051425 (2002-07-01), None
patent: 02/057287 (2002-07-01), None
patent: 02/057425 (2002-07-01), None
patent: 02/100415 (2002-12-01), None
patent: 03/015755 (2003-02-01), None
patent: 03/026589 (2003-04-01), None
patent: 03/026675 (2003-04-01), None
patent: 03/062192 (2003-07-01), None
patent: 03/062211 (2003-07-01), None
patent: 03/064455 (2003-08-01), None
patent: 03/068244 (2003-08-01), None
patent: 03/093290 (2003-11-01), None
patent: 03/099274 (2003-12-01), None
patent: 04/000858 (2003-12-01), None
patent: 2004/002422 (2004-01-01), None
patent: 2004/002999 (2004-01-01), None
patent: 2004/003000 (2004-01-01), None
patent: 2004/003138 (2004-01-01), None
patent: 2004/007512 (2004-01-01), None
patent: 2004/011478 (2004-02-01), None
patent: 2004/013300 (2004-02-01), None
patent: 2004/028481 (2004-04-01), None
patent: 2004/041201 (2004-05-01), None
patent: 2004/087714 (2004-10-01), None
patent: 2004/093915 (2004-11-01), None
patent: 2004/103996 (2004-12-01), None
patent: 2004/110442 (2004-12-01), None
patent: 2005/003147 (2005-01-01), None
patent: 2005/016927 (2005-02-01), None
patent: 2005/023819 (2005-03-01), None
patent: 2005/034941 (2005-04-01), None
patent: 2005/046712 (2005-05-01), None
patent: 2005/070955 (2005-08-01), None
patent: 2005/080399 (2005-09-01), None
patent: 2006/008556 (2006-01-01), None
patent: 2006/020082 (2006-02-01), None
patent: 2006/021341 (2006-03-01), None
patent: 2006/027628 (2006-03-01), None
patent: 2006/029912 (2006-03-01), None
patent: 2006/046030 (2006-05-01), None
patent: 2006/046039 (2006-05-01), None
patent: 2006/119061 (2006-11-01), None
patent: 2006/119975 (2006-11-01), None
patent: 2007/015787 (2007-02-01), None
patent: 2007/015855 (2007-02-01), None
patent: 2007/016441 (2007-02-01), None
patent: 2007/028789 (2007-03-01), None
patent: 2007/029029 (2007-03-01), None
patent: 2007/131966 (2007-11-01), None
patent: 2007/145894 (2007-12-01), None
patent: 2007/148135 (2007-12-01), None
patent: 2008/002924 (2008-01-01), None
patent: 2008/051475 (2008-05-01), None
patent: 2008/051477 (2008-05-01), None
patent: 2008/051514 (2008-05-01), None
patent: 2008/057028 (2008-05-01), None
patent: 2008/057208 (2008-05-01), None
patent: 2008/057209 (2008-05-01), None
patent: 2008/112108 (2008-09-01), None
patent: 2009/005687 (2009-01-01), None
patent: 2009/010804 (2009-01-01), None
patent: 2009/064955 (2009-05-01), None
patent: 2009/064975 (2009-05-01), None
patent: 2010/011566 (2010-01-01), None
Brian W. Dymock et al., “Novel Approaches to the Treatment of Hepatitis C Virus Infection,” 11 Antiviral Chemistry & Chemotherapy 79-96 (2000).
Hugo R. Rosen & David R. Gretch, “Hepatitis C virus: current understanding and prospects for future therapies,” 5 Molec. Med. Today 393-99 (1999).
Darius Moradpour & Hubert E. Blum, “Current and evolving therapies for hepatitis C,” 11 Euro. J. Gastroenterol. Hepatol. 1189-1202 (1999).
Ralf Bartenschlager, “Candidate Targets for Hepatitis C Virus-Specific Antiviral Therapy,” 40(5-6) Intervirology 378-93 (1997).
Georg M. Lauer & Bruce D. Walker, “Hepatitis C Virus Infection,” 345(1) N. Engl. J. Med. 41-52 (2001); correction: 345 (19) N. Engl. J. Med. 1425-26 (2001).
Brain W. Dymock, “Emerging therapies for hepatitis C virus infection,” 6 Emerging Drugs 13-42 (2001).
Charlene Crabb, Infectious Diseases. “Hard-Won Advances Spark Excitement about Hepatitis C,” Science 506-507 (2001).
Rogers E. Harry-O'Kuru et al., “A Short, Flexible Route toward 2′-C-Branched Ribonucleosides,” 62 J. Org. Chem. 1754-59 (1997).
Michael S. Wolfe & Rogers E. Harry-O'Kuru, “A Concise Synthesis of 2′-C-Methylribonucleosides,” 36(42) Tetrahedron Letters 7611-14 (1995).
Scott J. Miller et al., “Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides,” 118 J. Am. Chem. Soc. 9606-14 (1996).
Jason S. Kingsbury et al., “A Recyclable Ru-Based Metathesis Catalyst,” 121 J. Am. Chem. Soc. 791-99 (1999).
Matthias Scholl et al., “Synthesis and Activity of a New Generation of Ruthenium-Based Olefin Metathesis Catalysts Coordinated with 1,3-Dimesityl-4,5-dihydroimidazol-2-ylidene Ligands,” 1(6) Organic Letters 953-56 (1999).
Alois Furstner et al., “Total Synthesis and Structural Refinement of the Cyclic Tripyrrole Pigment Nonylprodigiosin,” 64 J. Org. Chem. 8275-80 (1999).
Tina M. Trnka & Robert H. Grubbs, “The Development of L2X2R-CHR Olefin Metathesis Catalysts: An Organometallic Success Story,” 34 Acc. Chem. Res. 18-29 (2001).
A. Srikrishna et al., “Enantiospecific Construction of the BC-ring System of Taxanes,” 45 Tetrahedron Letters 2939-42 (2004).
Yung-Son Hon et al., “Dibromomethane as one-carbon source in organic synthesis: a versatile methodology to prepare the cyclic and acyclic alpha-methylene or alpha-keto acid derivatives from the corresponding terminal alkenes,” 60 Tetrahedron 4837-60 (2004).
Eusebio Juaristi & Hugo A. Jimenez-Vazquez, “Single Electron Transfer Mechanism in the Reaction of 1,3-Dithianyllithium and Alkyl Iodides,” 56 J. Org. Chem. 1623-30 (1991).
Paola Conti et al., “Chemoenzymatic Synthesis of the Enantiomers of Desoxymuscarine,” 9 Tetrahedron: Asymmetry 657-65 (1998).
Robert M. Coates & Mark W. Johnson, “Stereoselective Synthesis of Moenocinol and Assignment of Its Carbon-13 Nuclear Magnetic Resonance Spectrum,” 45 J. Org. Chem. 2685-97 (1980).
D. Becker & N. Haddad, “Steric Effects in Intramolecular [2+
Harper Steven
Liverton Nigel J.
McCauley John A.
Summa Vincenzo
Heber Sheldon O.
Insituto di Ricerche di Biologia Molecolare P. Angeletti SpA
Kifle Bruck
Lake Julie M.
Merck Sharp & Dohme Corp.
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