Macrocyclic polyether carboxylic acids

Details Macrocyclic polyether carboxylic acids Macrocyclic polyether carboxylic acids

1988-09-06

1989-10-24

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549351, C07D32300

Patent

active

048763675

ABSTRACT:
A series of novel, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, containing six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention to ruminant animals (e.g. cattle and sheep) modifies their digestive fermentation processes such that the volatile fatty acids produced in the rumen contain a higher proportion of propionates rather than acetates, thereby increasing the efficiency of feed utilization in said ruminant animals. Additionally, the compounds of the invention show antibacterial activity in vitro against certain gram-positive microorganisms.

REFERENCES:
patent: 3580889 (1971-05-01), Barney et al.
patent: 3622577 (1971-11-01), Pedersen
patent: 3686225 (1972-08-01), Pedersen
patent: 3687978 (1972-08-01), Pedersen
patent: 3839557 (1974-10-01), Raun
patent: 3965116 (1976-06-01), Cram
patent: 3997565 (1976-12-01), Kauer
patent: 4072693 (1978-02-01), Reinhoudt et al.
patent: 4104275 (1978-08-01), Kauer
patent: 4152335 (1979-05-01), Reinhoudt et al.
patent: 4186175 (1980-01-01), Tomaja
Chemical Abstracts, vol. 87, 200604h (1977).
Chemical Abstracts, vol. 85, 46618r (1976).
Chemical Abstracts, vol. 85, 123893f (1976).
Chemical Abstracts, vol. 83, 192012p (1975).
Chemical Abstracts, vol. 96, 142822a (1982).
Chemical Abstracts, vol. 91, 107964y (1979).
Newcomb et al., J. Amer. Chem. Soc., vol. 97:5, 1257-1259 (1975).
Pedersen, C. J., J. Amer. Chem. Soc., vol. 92:2, 391-394 (1970).
Pedersen, C. J., Federation Proceedings, vol. 27, No. 6, 1305-1309 (1968).
Pedersen et al., Angew. Chem. Internat. Edit., vol. 11, 16-25 (1972).
Blair et al., J. Chem. Soc., Perkin I, No. 3, 245-250 (1975).
Opella et al., J. Am. Chem. Soc., vol. 96 (22), 1974, pp. 7159-7160.
Bell et al., J. Am. Chem. Soc., vol. 104 (19), 1982, pp. 5185-5188.

Affiliated with

Also associated with

Rating

Macrocyclic polyether carboxylic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Macrocyclic polyether carboxylic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Macrocyclic polyether carboxylic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1590354