Macrocyclic lactones

Details Macrocyclic lactones Macrocyclic lactones

1983-07-12

1985-12-24

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514450, C07D49322

Patent

active

045607745

ABSTRACT:
New and exceptionally potent antineoplastic agents designated bryostatin 1, bryostatin 2 and bryostatin 3 have been isolated from the marine animal Bugula neritina L. (Bryozoan phylum). An x-ray crystallographic analysis led to the assignment of novel structures shown in Charts I, II and III.

REFERENCES:
G. G. Villela, Proc. Soc. Exptl. Biol. Med., 68, 531-533, (1948).
J. S. Carle, et al., J. Org. Chem., 45, 1586-1589, (1980).
J. S. Carle, et al., J. Org. Chem., 46, 3440-3443, (1981).
Y. Okami, et al., J. Antibiot., 29, 1019-1025, (1976).
H. Nakamura, et al., J. Antibiot., 30, No. 9, 714-719, (1977).
G. R. Pettit, et al., Nature, 227, 962-963, (1970).

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