Macrocyclic lactone HMG-CoA reductase inhibitors

Details Macrocyclic lactone HMG-CoA reductase inhibitors Macrocyclic lactone HMG-CoA reductase inhibitors

1985-11-04

1987-05-12

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549267, C07D32100, A61K 31365

Patent

active

046650911

ABSTRACT:
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): ##STR1## are disclosed. Also disclosed are pharmaceutical compositions and methods of use of the compounds of formula (I).

REFERENCES:
patent: 4239690 (1980-12-01), Gurusiddaiah et al.

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