Macrocyclic kinase inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S267000

Reexamination Certificate

active

07601852

ABSTRACT:
A compound having a structure according to formula Iwherein R1, R2, R3, R4, and R5are as defined herein, are useful as kinase inhibitors.

REFERENCES:
patent: 5795910 (1998-08-01), Giese
patent: 6635671 (2003-10-01), Kastelic et al.
patent: 2004/0224936 (2004-11-01), Chiba
patent: 2005/0182129 (2005-08-01), Ikeda
patent: 2005/0256183 (2005-11-01), Kasibhatla
patent: 2006/0079494 (2006-04-01), Santi
patent: 2006/0094674 (2006-05-01), Neel
patent: 0606044 (1994-07-01), None
patent: 2323845 (1998-10-01), None
patent: 2323845 (1998-10-01), None
patent: 08-040893 (1996-02-01), None
patent: 2001-294527 (2001-10-01), None
patent: WO 02/48135 (2002-06-01), None
patent: WO 02/48136 (2002-06-01), None
Patani et al. Chem.Rev. 1996, 96, 3147-3176.
Horn et al. J. Med. Chem. 1984,27, 1340-1343.
Davies et al.,Nature2002, 417, 949-954, “Mutations of the BRAF Gene in Human Cancer”.
Dombrowski et al.,J. Antibiotics1999, 52 (12), 1077-1085, “Production of a Family of Kinase-Inhibiting Lactones from Fungal Fermentations”.
Ellestad et al.,J. Org. Chem. 1980, 43 (12), 2339-2343, “New Zearalenone Related Macrolides and Isocoumarins from an Unidentified Fungus”.
Nair et al.,Tetrahedron Letters1980, 21 (21), 2011-2012, “Metabolites of pyrenomycetes. XIII. Structure of (+)-hypothemycin, an antibiotic macrolide fromHypomyces trichothecoides” (abstract).
Sausville et al.,Ann. Rev. Pharmacol. Toxicol. 2003, 43, 199-231, “Signal Transduction-Directed Cancer Treatments”.
Selles et al.,Tetrahedron Letters2002, 43 (26), 4627-4631, “Convergent stereospecific synthesis of LL-Z1640-2 (or C292), hypothemycin and related macrolides. Part 2”.
Tatsuta et al.,Chemistry Letters2001, 2, 172-173, “The First Total Synthesis of a Macrocyclic Antiprotozoan, LI-Z1640-2”.
Wermuth, ed.,The Practice of Medicinal Chemistry, 2nd Ed., pp. 561-586 (Academic Press 2003).
Williams et al.,Biochemistry1998, 37, 9579-9585, “Ro 09-2210 Exhibits Potent Antiproliferative Effects on Activated T Cells by Selectively Blocking MKK Activity”.
Patani et al., Bioisosterism: A Rational Approach in Drug Design, Chem. Rev., vol. 96, pp. 3147-3176 (1996).

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