Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-12-17
1999-09-14
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540453, 540454, 540455, 540456, 540457, 540458, 540459, 540460, 540461, 540463, A61K 3133, C07D22504, C07D26722, C07D28118
Patent
active
059523204
ABSTRACT:
Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
REFERENCES:
patent: 4996358 (1991-02-01), Handa et al.
patent: 5300501 (1994-04-01), Porter
patent: 5442110 (1995-08-01), Isomura et al.
Nature vol. 370 Aug. 18, 1994, pp. 555-557 "Processing of tumor necrosis factor-.alpha. precursor by metalloproteinases."
Nature vol. 370 Jul. 21, 1994, pp. 218-220 "Protection against a lethal dose of endotoxin be an inhibitor of tumor necrosis factor processing."
Nature vol. 370 Aug. 18, 1994, pp. 558-561 "Regulation of tumour necrosis factor-.alpha. processing by a metalloproteinase inhibitor."
F.B. Ibrahim, "Quantitative Determination of Oxaprozin and Several of its Related Compounds by high Performance Reversed-Phase Liquid Chromatography", J. Liq. Chromatogr., vol. 18, No. 13, (1995), 2621-2633.
J. Wyeth et al., "Identification of Impurities in a Novel Antiinflammatory Oxazole Derivative", Proc. Soc. Anal. Chem., vol. 9, No. 2, (1972), pp.; 32-35. propionic acid and derivatives, Brit. 4 pp., Addn. to. Brit. 1,206,403. (abstract), 1974.
F.W. Short et al., Synthesis of 5-aryl-2-oxazolepropionic Acids Analogs. Antiinflammatory Agents, J. Heterocycl. Chem., vol. 6, No. 5, (1969), pp. 707-712.
CAS Online printout of WO 97/18207, May 1997.
Davidsen Steven K.
Florjancic Alan S.
Guo Yan
Holms James H.
Michaelides Michael R.
Abbott Laboratories
Coleman Brenda
Shah Mukund J.
Steele Gregory W.
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