Macrocyclic inhibitors of matrix metalloproteinases and TNF.alph

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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540453, 540454, 540455, 540456, 540457, 540458, 540459, 540460, 540461, 540463, A61K 3133, C07D22504, C07D26722, C07D28118

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active

059523204

ABSTRACT:
Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.

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F.B. Ibrahim, "Quantitative Determination of Oxaprozin and Several of its Related Compounds by high Performance Reversed-Phase Liquid Chromatography", J. Liq. Chromatogr., vol. 18, No. 13, (1995), 2621-2633.
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F.W. Short et al., Synthesis of 5-aryl-2-oxazolepropionic Acids Analogs. Antiinflammatory Agents, J. Heterocycl. Chem., vol. 6, No. 5, (1969), pp. 707-712.
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