Macrocyclic inhibitors of hepatitis C virus

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S365000, C514S312000, C540S460000

Reexamination Certificate

active

07989471

ABSTRACT:
Inhibitors of HCV of formula (I)and the N-oxides, salts, and stereochemically isomeric forms thereof, wherein the terms R1, L, R2, R3, R4, and n have specific definitions; pharmaceutical compositions containing compounds of formula (I), and processes for preparing compounds of formula (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.

REFERENCES:
patent: 5484801 (1996-01-01), Al-Razzak
patent: 5807876 (1998-09-01), Armistead et al.
patent: 5948436 (1999-09-01), Al-Razzak et al.
patent: 6037157 (2000-03-01), Norbeck et al.
patent: 6054472 (2000-04-01), Armistead et al.
patent: 6344465 (2002-02-01), Armistead et al.
patent: 6498178 (2002-12-01), Stamos et al.
patent: 6562806 (2003-05-01), Thurston et al.
patent: 7659245 (2010-02-01), Simmen et al.
patent: 7666834 (2010-02-01), Simmen et al.
patent: WO 9414436 (1994-07-01), None
patent: WO 9507696 (1995-03-01), None
patent: WO 9509614 (1995-04-01), None
patent: WO 9740028 (1997-10-01), None
patent: WO 9817679 (1998-04-01), None
patent: WO 9822496 (1998-05-01), None
patent: WO 9840381 (1998-09-01), None
patent: WO 9907734 (1999-02-01), None
patent: WO 0056331 (2000-09-01), None
patent: WO 0059929 (2000-10-01), None
patent: WO 0218369 (2002-03-01), None
patent: WO 03087092 (2003-10-01), None
patent: WO 2005073195 (2005-08-01), None
patent: WO 2005073216 (2005-08-01), None
Poirier et al. , Journal of Organic Chemistry, 2005, 70: 10765-10773.
Bodanszky, M., “Peptide Chemistry”, 2ndRed.Ed., Springer-Verlag, Berlin, Germany (1993).
Bredikhina, Z, et al., “Synthesis and some Reactions of 4-Carboxy-2-Tiliazolylyydrazones”, Chem. Hyterocycl. Compd. (English translation) (1991), 427-433.
Brown, Frederick J., et al., Hydroxyacetophenone-Derived Antagonists of the Peptidoleukotrienes; J.Med.Chem., 1989, 32, pp. 807-826.
Elangovan et al., “Sonogashira Coupling Reaction with Diminished Homocoupling”, Organic Letters 2003 vol. 5 No. 11 pp. 1841-1844.
Greene, “Protective Groups in Organic Chemistry”, Wiley, John & Sons, New York (1999) and “The Peptides: Analysis, Synthesis, Biology”, vol. 9, Academic Press, NY (1987).
Huang, et al., “Olefin Metathesis-Active Ruthenium Complexes Bearing a Nucleophilic Carbene Ligand” J.Am. Chem. Soc. 1999 121, p. 2674-2678.
Kingsbury, JA.. “A Recyclable Ru-Based Metathesis Catalyst”, et al., J.Am. Chem. Soc. 1999, 121, p. 791-799.
Krchnak, V. et al., “Polymer-Supported Mitsunobu Ether Formation and its Use in Combinatorial Chemistry”, Tetrahedron Letters, vol. 36, No. 35, p. 6193-6195, 1995.
Krieger, N., et al., “Enhancement of Hepatitis C Virus RNA Replication by Cell Culture-Adaptive Mutations”, Journal of Virology, May 2001, pp. 4614-4624.
Lohmann, V., et al., “Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line”, Science 285, 1999, pp. 110-113.
Mitsunobu, O., et al. “The Use of Diethyl Azodicrboxylate and Triphenylphospine in Synthesis and Transformation of Natural Products”, Synthesis, 1981 pp. 1-28.
Miller, S., et al., “Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides”, J.Am. Chem. Soc. 1996, 118, p. 9606-9614.
Rano, Thomas A. and Chapman, K., “Solid Phase Synthesis of Aryl Ethers via the Mitsunobu Reaction”, Tetrahedron Letters, vol. 36, No. 22, pp. 3789-3792, 1995.
Richter, L.S., Gadek, T.R., “A Surprising Observation about Mitsunobu Reactions in Solid Phase Synthesis”, Tetrahedron Letters, vol. 35, No. 27, p. 4705-4706, 1994.
Smith, E.M., et al., “Synthesis and Pharmacological Activity of Angiotensin Converting Enzyme Inhibitors: N-(Mercaptoacyl)-4-Substituted-(S-Prolines”, (J. Med. Chem. (1988), 31, 875-885.

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