Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1995-12-15
1997-02-04
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D49612, A61K 3133
Patent
active
055999271
ABSTRACT:
Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein X is a substituent selected from among radicals having the subformulae ##STR2## and other heterocyclic radicals, as well as pharmaceutical compositions and methods of immunomodulatory treatment utilizing the same.
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Schreiber, S. L., et al., "The mechanism of action of Cyclosporin A and FK 506", Immunology Today, 13(4): 136-142 (1992).
Hauske, J. R., et al., "Design and Synthesis of Novel FKBP inhibitors", J. Chem., 35(23): 4284-4296 (1992).
Schreiber, S. L., "Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands", Science, 251: 283-287 (Jan. 1991).
Batchelor, M. J., et al., "Total Synthesis of Close analogues of the Immunosupressant FK 506", Tetrahedron, 50(3): 809-826 (1994).
Zimmer, R., et al., "Synthetic Modifications of Asomycin-I. A Chemoselective Removal of the Cyclohexyl Residue of Asomycin", Tetrahedron, 50(48): 13655-13670 (1994).
Luly Jay R.
Or Yat S.
Abbott Laboratories
Bond Robert T.
Crowley Steven R.
Steele Gregory W.
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