Macrocyclic dyes having naphthyl moieties

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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Reexamination Certificate

active

08034927

ABSTRACT:
Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.

REFERENCES:
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patent: 4314058 (1982-02-01), Hayami et al.
patent: 5439797 (1995-08-01), Tsien et al.
patent: 6074834 (2000-06-01), Slezak et al.
patent: 7456810 (2008-11-01), Kimura
Wolf, David E., “Determination of the sidedness of carbocyanine dye labeling of membranes,” Biochemistry (1985) vol. 24, pp. 582-585.
Chen, Ping, et al., “Structure and solvent effective on the photostability of indolenine cyanine dyes,” Elsevier Science Ltd., Dyes and Pigments (1999) vol. 41, pp. 227-331.

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