Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-30
1996-12-03
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514183, 540450, 540467, 540468, 540469, C07D49800, C07D27308, A61K 3133
Patent
active
055809006
ABSTRACT:
A compound of the formula: ##STR1## in which each R.sup.1 to R.sup.4 group is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy-carbonyl, halo, hydroxy, nitro, cyano, trihalomethyl or optionally substituted phenyl, each R.sup.5 to R.sup.16 group is hydrogen or C.sub.1-4 alkyl, each Z', Z", Z'" and Z"" group is an alkylene radical, and X and Y are each --(CH.sub.2).sub.n -- or --(CH.sub.2).sub.m --A--(CH.sub.2).sub.p -- where A is --CH.dbd.CH--, optionally substituted phenylene or optionally substituted naphthalenyl, n is 2 to 10, and m and p are each 1 or 2, salts thereof, and intermediates for the production thereof.
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Martin J. Grannas, et al., "Synthesis and X-ray Crystal Structures of a Calixarene-Related, tetraamino, Tetraphenolic, Polynucleating Macrocyclic Ligand and Its Zn.sup.II.sub.4 and Co.sup.III.sub.3 Derivatives" Inorg. Chemistry 33: 1071-1079 (1994).
Harvey T. McMahon and David G. Nicholls, "Transmitter Glutamate Release from Isolated Nerve Terminals: Evidence for Biphasic Release and Triggering by Localized Ca.sup.2+ " J. of Neurochemistry 56: 86-94, (1991).
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Clark Barry P.
Harris John R.
Boone David E.
Caltrider Steven P.
Lilly Industries Limited
Shah Mukund J.
Sripada Pavanaram
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