Macrocyclic complexes of technetium-99m for use as diagnostic ra

Details Macrocyclic complexes of technetium-99m for use as diagnostic ra Macrocyclic complexes of technetium-99m for use as diagnostic ra

1983-04-25

1986-10-07

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 534 14, A61K 4300, A61K 4900

Patent

active

046158766

ABSTRACT:
Stable neutral-lipophilic complexes of technetium-99m (Tc-99m) useful as diagnostic radionuclidic imaging agents are formed by complexing technetium-99m pertechnetate with alkylene amine oximes (viz. propylene amine oxime) in aqueous solutions under reducing conditions. The complexes have a zero charge, contain an O--H--O ring closure bond, and are sufficiently stable for parental administration in imaging by scintillation scanning. Substituents can be attached to the C.sub.2 to C.sub.4 alkylene carbon backbone of the tetradentate amine oxime ligands to structurally modify them and produce a variety of Tc-99m-radiopharmaceuticals with specific body imaging applications.

REFERENCES:
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4360511 (1982-11-01), Baldwin et al.
patent: 4363793 (1982-12-01), Blau et al.
Karesh et al, J. Pharmaceutical Sciences, 66 (1977) 225-8.
Eckelman et al. J. Pharmaceutical Sciences, 64 (1975) 704-6.

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