Macrocyclic bifunctional chelating agents

Details Macrocyclic bifunctional chelating agents Macrocyclic bifunctional chelating agents

1985-07-02

1987-07-07

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Lymphokine

540465, 424 9, A61K 3900, A61K 3942, A61K 4300, A61K 4900

Patent

active

046786678

ABSTRACT:
A copper chelate conjugate which is stable in human serum. The conjugate includes the copper chelate of a cyclic tetraaza di-, tri-, or tetra-acetic acid, a linker attached at one linker end to a ring carbon of the chelate, and a biomolecule joined at the other end of the linker. The conjugate, or the linker-copper chelate compound used in forming the conjugate, are designed for use in diagnostic and therapeutic applications which involve Cu(II) localization via the systemic route.

REFERENCES:
patent: 4472509 (1984-09-01), Gansow et al.
Tabushi, I., et al, Tetrahedron Letters (1977), 12:1049.
Delgado, R., et al, Talanta (1982), 29:815.
Stetter, H., et al, Tetrahedron Letters (1981), 37:767.
Bearn, A. B., et al, Proc. Soc. Exp. Biol. Med. (1954), 85:44.
Leung, C. S.-H., et al, International J. Applied Radiation and Isotopes (1978), 29:687.
Meares, C. F., et al, Anal. Biochem. (1984), 142:68.
Meares, C. F., et al, Accts. Chem. Res. (1984), 17:202.

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