Macrocyclic aminophosphonic acid complexes, their formulations a

Details Macrocyclic aminophosphonic acid complexes, their formulations a Macrocyclic aminophosphonic acid complexes, their formulations a

1989-12-19

1991-11-12

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 252625, A61K 4300, C07F 500

Patent

active

050646338

ABSTRACT:
Particle emitting radionuclides, e.g. X-90, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions and formulations for the therapeutic treatment of calcific tumors and the relief of bone pain in animals.

REFERENCES:
patent: 4639365 (1987-01-01), Sherry
patent: 4647447 (1987-03-01), Gries et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4808541 (1989-02-01), Mikola et al.
patent: 4882142 (1989-11-01), Simon
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 4897254 (1990-01-01), Simon et al.
patent: 4898724 (1990-02-01), Simon et al.
Inorganic Chimica Acta 137-139 (1987).
J. Magn. Reson. 76, 528 (1988).
Inorganic Chem 28(17), 3336-3341 (1989).

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