Macrocyclic aminophosphonic acid complexes for the treatment of

Details Macrocyclic aminophosphonic acid complexes for the treatment of Macrocyclic aminophosphonic acid complexes for the treatment of

1988-12-19

1991-10-22

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 424 9, 424DIG6, A61K 4300, C07F 500

Patent

active

050594125

ABSTRACT:
Particle emitting radionuclides, e.g. Samarium-153, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions and formulations for the therapeutic treatment of calcific tumors in animals.

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Inorg. Chem. 28(17), 3336-3341 (1989); Three cyclic Aminomethylenephosphonic acids.
Inorganica Chim. Acta 139, 137-139, (1987); DOTMP complexed.
J. Magn. Reson. 76, 528-533 (Feb. 1988); First use of the Dy-DOTMP complex.
Izv. Akad. Nauk. SSSR, Ser. Khim. 4, 835-843 (Apr. 1964), Trans. in Bull. Acad. Sci. USSR, Div. of the Chem. Sci 33(4), 769 (Apr. 1984); cyclic amino phosphonic acids.
Izv. Akad. Nauk. SSSR, Ser. Khim. 4, 844-849 (Apr. 1984), Trans. in Bull. Acad. Sci. USSR, Div. of the Chem. Sci. 33(4), 777 (Apr. 1984); Synthesis of DOTMP from the cyclic amine.
Teor. Eksp. Khim. 21(6), 660-669 (Nov.-Dec. 1985); A theoretical conformational analysis of DOTMP and a triazacyclic phosphonic acid.
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