Macrocyclic amide and urea immunomodulators

Details Macrocyclic amide and urea immunomodulators Macrocyclic amide and urea immunomodulators

1996-04-19

1998-03-24

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, 514183, 540456, A61K 31395, C07D49116

Patent

active

057313202

ABSTRACT:
Immunomodulatory macrocyclic compounds having the formula: ##STR1## and pharmaceutically-acceptable salts, esters, amides and prodrugs thereof, as well as pharmaceutical compositions containing the same, which possess immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative activity, as well as the ability to reverse chemotherapeutic drug resistance.

REFERENCES:
patent: 5162334 (1992-11-01), Goulet et al.
patent: 5250678 (1993-10-01), Goulet et al.
patent: 5252732 (1993-10-01), Sinclair et al.
patent: 5457111 (1995-10-01), Luly et al.

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