Macrocyclic 13-membered ring derivatives of erythromycins A and

Details Macrocyclic 13-membered ring derivatives of erythromycins A and Macrocyclic 13-membered ring derivatives of erythromycins A and

1996-06-18

1998-01-27

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 29, 536 71, 536 72, A61K 3170, C07H 1708

Patent

active

057122539

ABSTRACT:
Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R, R.sup.1, R.sup.2, R.sup.3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

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patent: 4677097 (1987-06-01), Omura et al.
patent: 4681872 (1987-07-01), Freiberg et al.
patent: 4833236 (1989-05-01), Morimoto et al.
patent: 4948782 (1990-08-01), Omura et al.
Zeitschrift Fur Gastroenterologie, vol. 29 (1991), pp. 27-30, H.D. Allescher, "Medikamentose Beeinflussung der Gastro-Intestinalen Motilitat und Sekretion".
Journal of Organic Chemistry, vol. 61, No. 15 (Jul. 1996), pp. 5153-5154, P.A. Lartey et al., "A Novel 13-Membered Erythromycin Analog via Dast-Induced Ring Contraction".
Tsuzuki, K., "Motilides, Macrolides with Gastrointestinal Motor Stimulating Activity.sup.1) l. O-Substituted and Tertiary N-Substituted Derivatives of 8,9-Anhydroerythromycin A 6,9-Hemiacetal", Chem. Pharm. Bull., vol. 37, No. 10, Oct., 1989, pp. 2687-2700.

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