Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-06-27
2006-06-27
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S456000
Reexamination Certificate
active
07067507
ABSTRACT:
The present invention is macrocycles of the formula (X):for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
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Proc. Natl. Acad. Sci, Vol. 87, pp. 8805-8809, Nov. 1990, Swain et al.
J. Am. Chem. Soc., Vol. 117, pp. 10220-10226, Oct. 1995/ Abbenante et al.
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Current Medicinal Chemistry, 2001, 8(8), 893-907 Tyndall et al.
Beck James P.
Jacobs Jon S.
Pulley Shon R.
TenBrink Ruth E.
Kifle Bruck
McDonnell & Boehnen Hulbert & Berghoff
Pharmacia & Upjohn Company
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