Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-11-29
2005-11-29
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S456000
Reexamination Certificate
active
06969709
ABSTRACT:
The present invention are macrocycles of the formula (IX):for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
REFERENCES:
patent: 6043357 (2000-03-01), Abbenante et al.
patent: WO 96/16950 (1996-06-01), None
J. Med. Chem. 2000, 43, 1271-1281.
Proc. Natl. Acad. Sci, vol. 87, pp. 8805-8809, Nov. 1990. Swain et al.
J. Am. Chem. Soc., vol. 117, pp. 10220-10226, Oct. 1995. Abbenante et al.
J. Med. Chem. 2000, 43, 3495-3504 Tyndall et al.
J. Med. Chem 2002, 45 (2), 371-381 Glenn et al.
Current Medicinal Chemistry, 2001 8(8), 893-907 Tyndall et al.
Beck James P.
Pulley Shon R.
TenBrink Ruth E.
Kifle Bruck
McDonnell & Boehnen Hulbert & Berghoff
Pharmacia & Upjohn Company
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