Macrocapsules prepared from crosslinkable polysaccharides, polyc

Details Macrocapsules prepared from crosslinkable polysaccharides, polyc Macrocapsules prepared from crosslinkable polysaccharides, polyc

1995-06-07

1998-12-08

Berman, Susan W.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

424460, 424461, 424462, 424486, 424487, 424488, 424 931, 522 87, 522 88, A61K 962, A61K 964, A61K 956

Patent

active

058465308

ABSTRACT:
The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.

REFERENCES:
patent: 4353888 (1982-10-01), Sefton
patent: 4450233 (1984-05-01), Mimura et al.
patent: 4806355 (1989-02-01), Goosen et al.
patent: 5084350 (1992-01-01), Chang et al.
patent: 5158881 (1992-10-01), Aebischer et al.
patent: 5334640 (1994-08-01), Desai et al.
patent: 5529914 (1996-06-01), Hubbell et al.
patent: 5545423 (1996-08-01), Soon-Shiong et al.
patent: 5550050 (1996-08-01), Holland et al.
Abuchowski et al., "Alteration of Immunological Properties of Bovine Serum Albumin by Covalent Attachment of Polyethylene Glycol" J. Biol. Chem. 252:3578-3581 (1977).
Braun et al., "The encapsulation of pancreatic islets. Investigation of insulin secretion and content in vitro" Biochim. Acta 44:143-147 (1995).
Chang, "Microencapsulation and Artificial Cells" Humana Press, Clifton, NJ, pp. 4-26 (1984).
Chang, "Artificial Cells in Medicine and Biotechnology" Humana Press, 10: 4-24 (1984).
Darquy and Reach "Immunoisolation of pancreatic B cells by microencapsulation" Diabetologia 28:776-780 (1985).
Decker and Moussa, "Real-Time Kinetic Study of Laser-Induced Polymerization" Macromolecules 22:4455-4461 (1989).
Desai and Hubbell "Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials" Biomaterials 12:144-153 (1991).
Dupuy et al., "Agarose Beads in Paraffin Oil as Interfaces to Encapsulate Living Cells. Tests of function with Islets of Langerhans" Artif. Organs 11:314 (1987).
Dupuy et al., In situ polymerization of a microencapsulating medium round living cells Journal of Biomedical Materials Research 22:1061-1070 (1988).
Eaton, David F., "Dye Sensitized Photopolymerization" Advances in Photochemistry 13:427-487 (1986).
Gharapetian et al., "Encapsulation of Viable Cells Within Polyacrylate Membranes" Biotech. Bioeng. 28:1595-1600 (1986).
Goosen et al., "Optimization of Microencapsulation Parameters: Semipermeable Microcapsules as a Bioartificial Pancreas" Biotechnol. Bioeng. 27:146-150 (1985).
Harris, J. Milton, "Laboratory Synthesis of Polyethylene Glycol Derivatives" JMS-Rev. Macromol. Chem. Phys. C25(3):325-373 (1985).
Harris et al., "Synthesis and Characterization of Poly(ethylene Glycol) Derivatives" J. Polym. Sci., Polym. Chem. Ed. 22:341-352 (1984).
Hoyle et al., "Laser-Pulsed Photopolymerization of Methyl Methacrylate: The Effect of Repetition Rate" Macromolecules 22:3866-3871 (1989).
Iwata et al., "Evaluation of Microencapsulated Islets in Agarose Gel as Bioartificial Pancreas by Studies of Hormone Secretion in Cultrue and by Xenotransplantation" Diabetes 38(1):224-225 (1989).
Karu, T. I., "Effects of Visible Radiation on Cultured Cells" Photochem. and Photobiol. 52:1089-1098 (1990).
Lanza et al., "Large-Scale Canine and Human Islet Isolation Using a Physiological Islet Purification Solution" Diabetes 39:309A (1990).
Lim and Sun, "Microencapsulated Islets as Bioartificial Endocrine Pancreas" Science 210:908-910 (1980).
Mathias et al., "Synthesis and Polymerization of Mono-and Divinyl Ethers of Oligooxyethylenes" J. Polym. Sci., Polym. Lett. Ed. 20:473-479 (1982).
Moe et al., "Covalently cross-linked sodium alginate beads" Food Hydrocolloids 5:119-123 (1991).
Morrison and Boyd, "Organic Chemistry" Organic Chemistry, Allyn and Bacon, pp. 756-757 (1973).
Pitha et al., "Detergents Linked to Polysaccharides: Preparation and Effects on Membranes and Cells" Eur. J. Biochem. 94:11-18 (1979).
Sefton et al., "A HEMA-MMA Copolymer for the Microencapsulation of Mammalian Cells" Polymer Preprints 31:217-218 (1990).
Smidsrod and Skjak-Braek, "Alginate as immobilization matrix for cells" Trends in Biotechnology 8:71-78 (1990).
Soon-Shiong et al., "Islet Purification by a Novel Immunomicrosphere Cell Depletion Technique" Transplantation Proceedings 22(2):780-781 (1990).
Soon-Shiong et al., "An Immunologic Basis for the Fibrotic Reaction to Implanted Microcapsules" Transplantation Proceedings 23(1):758-759 (1991).
Wu, David S., "Optical-scanner design impacts rapid laser prototyping" Laser Focus World pp. 99-106 (Nov. 1990).

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