Macroaggregates for radiation synovectomy

Details Macroaggregates for radiation synovectomy Macroaggregates for radiation synovectomy

1988-10-13

1990-04-10

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

423 2, 600 3, 128659, 252625, 252645, A61K 4300, A61B 600, C09K 1104, C01G 5700

Patent

active

049159321

ABSTRACT:
A formulation is provided for the treatment of synovial inflammation, the formulation consisting of dysprosium-165 hydroxide macroaggregates or yttrium-90 hydroxide macroaggregates, wherein the formulation is substantially devoid of other co-precipitating agents in particular, ferric hydroxide. A method of treatment of synovial inflammation is also provided in which the method comprises adminstering an intra-articular injection of the above formulation. Preferably the above formulation is in the form of a isotonic apyrogenic injectable solution.

REFERENCES:
patent: 4752464 (1988-06-01), Lieberman et al.
Sledge, C. B. et al., "Experimental Radiation Synovectomy by DY-165 Ferric Hydroxide Macroaggregate", Arth. & Rhemat, vol. 20, No. 7, (9-10/1977).

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