Machine for metering liquid pharmaceutical products

Fluent material handling – with receiver or receiver coacting mea – Plural filling means – For plural receivers simultaneously filled

Reexamination Certificate

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Details

C141S135000, C141S144000, C141S145000, C141S147000, C141S152000, C141S238000, C141S094000, C141S095000, C222S144000

Reexamination Certificate

active

06237650

ABSTRACT:

The present invention relates to a machine for metering liquid pharmaceutical products into capsules or phials.
BACKGROUND OF THE INVENTION
As is known, most currently used machines for metering liquid pharmaceutical products are what are known in the sector as “reciprocating machines”, which substantially comprise a first body operating in steps and supporting a number of capsules in a spoke arrangement; a second body with internal channels and which rotates between two positions; a hopper full of liquid; and a number of hydraulic pistons. The second body, in a first position, connects the hopper hydraulically to the pistons into which a predetermined quantity of liquid is drawn, and, in a second position, connects the pistons hydraulically to respective capsules, which are arrested, for a predetermined time beneath the second body, pending injection of the liquid by the pistons into the capsules.
Machines of the above type have several drawbacks. In particular, as compared with continuously operating machines of the same overall size, reciprocating types provide for a much lower output rate per hour of capsules. What is more, at each operating step, reciprocating machines generate even severe vibration resulting not only in wear of the machine components but also in spillage of the liquid from the injected capsules, which in turn leads to other, no less serious, drawbacks, such as inaccurate filling of the capsules and fouling, or even stoppage, of the machine as a whole. Finally, on account of the cost and complications involved, reciprocating machines sometimes feature no devices for detecting the presence of capsules inside the respective seats, which, in the event of any missing capsules, results in further fouling and consequent stoppage of the machine.
To eliminate the above drawbacks of reciprocating machines, the present Applicant has devised a continuously operating machine as described in European Patent Application nr 91105443.5 filed on Apr. 5, 1991, and which comprises a rotary vessel full of liquid; a body having a number of hydraulic pistons; and a number of valves for channeling the liquid from the vessel to the pistons, and from the pistons to the capsules. The valves are slide types and are movable, along respective longitudinal axes, between a first position hydraulically connecting the vessel to the pistons, and a second position hydraulically connecting each piston to a corresponding capsule.
While undoubtedly affording advantages as compared with reciprocating machines, the above continuously operating machine also involves a number of drawbacks, especially at high speed. In particular, operation of the slide valves also results in vibration, which may even reach severe proportions at high speed, thus also resulting, albeit to a lesser degree than with reciprocating machines, in wear of the component parts of the machine, possible spillage, inaccurate filling of the capsules, and fouling of certain parts of the machine. Also, the seals on the slide valves are subject to rapid wear by the axial movement of the valves, thus resulting in all the drawbacks mentioned above relative to spillage on the outside of the machine.
SUMMARY OF THE INVENTION
It is an object of the present invention to provide a machine for metering liquid pharmaceutical products, designed to eliminate the aforementioned drawbacks.
According to the present invention, there is provided a machine for metering liquid pharmaceutical products into bottom shells, comprising:
a bottom part rotating about a respective vertical axis;
at least one first vertical through hole formed in said bottom part;
at least one piston moved in reciprocating manner along said first hole by a first device;
a bottom-shell belt meshing with a portion of said bottom part and traveling along the whole of the system of which said machine forms part;
a rotary top part having a vessel containing said pharmaceutical product;
a rotary central part coaxial and angularly integral with said bottom part and said top part;
drive means for driving said parts;
at least one second hole associated with said first hole and formed radially along said central part; and
at least one valve housed in said second hole;
characterized in that a first and a separate second channel are formed in said valve; and by comprising a second device for rotating said valve, about a horizontal axis, between a first angular position in which said first channel hydraulically connects the inside of said vessel to a metering chamber defined along said first hole, and a second angular position in which said second channel hydraulically connects said chamber to the inside of said bottom shell.


REFERENCES:
patent: 3580302 (1971-05-01), Riesenberg
patent: 4060109 (1977-11-01), Sotoma
patent: 4508148 (1985-04-01), Trechsel et al.

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